Effect of rhPDGF gel on wound healing as well as inflammation and angiogenesis in the wound of rats with diabetes ulcer  

作　　者：Ming-Cai Wang Xiao-Hua Yin 

机构地区：[1]Endocrinology Department,Zigong First People’s Hospital in Sichuan Province,Zigong 643000,China

出　　处：《Journal of Hainan Medical University》2017年第3期9-12,共4页海南医学院学报（英文版）

摘　　要：Objective:To study the effect of recombinant human platelet-derived growth factor (rhPDGF) gel on wound healing as well as inflammation and angiogenesis in the wound of rats with diabetes ulcer. Methods:Clean male Wistar rats were selected as the research objects, made into diabetes ulcer models and then divided into model group, low dose group and high dose group who received blank gel, 30μg/g rhPDGF gel and 100μg/g rhPDGF gel respectively for intervention. 4, 6, 8 and 10 d after intervention, the area of ulcer wound was observed;6 and 10 d after intervention, wound tissue was collected to detect the expression of inflammation and angiogenesis molecules. Results:4, 6, 8 and 10 d after intervention, ulcer wound area of low dose group and high dose group were significantly less than those of model group (P<0.05), and ulcer wound area of high dose group were significantly less than those of low dose group (P<0.05);6 and 10 d after intervention, TNF-αand IL-2 levels in ulcer wounds of low dose group and high dose group were significantly lower than those of model group (P<0.05) while VEGF, eNOS and NO levels were significantly higher than those of model group (P<0.05);TNF-αand IL-2 levels in ulcer wounds of high dose group were significantly lower than those of low dose group (P<0.05) while VEGF, eNOS and NO levels were significantly higher than those of low dose group (P<0.05). Conclusions:rhPDGF gel has promoting effect on the wound healing in rats with diabetes ulcer, and can also inhibit inflammation and promote angiogenesis.

关 键 词：Type 2 DIABETES mellitus ULCER WOUND PLATELET-DERIVED growth factor INFLAMMATION ANGIOGENESIS 

分 类 号：R73[医药卫生—肿瘤]