Alcohol,inflammation,and gut-liver-brain interactions in tissue damage and disease development  

作　　者：H Joe Wang Samir Zakhari M Katherine Jung 

机构地区：[1]Division of Metabolism and Health Effects, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health

出　　处：《World Journal of Gastroenterology》2010年第11期1304-1313,共10页世界胃肠病学杂志（英文版）

摘　　要：Chronic inflammation is often associated with alcoholrelated medical conditions. The key inducer of such inflammation, and also the best understood, is gut microflora-derived lipopolysaccharide (LPS). Alcohol can significantly increase the translocation of LPS from the gut. In healthy individuals, the adverse effects of LPS are kept in check by the actions and interactions of multiple organs. The liver plays a central role in detoxifying LPS and producing a balanced cytokine milieu. The central nervous system contributes to anti-inflammatory regulation through neuroimmunoendocrine actions. Chronic alcohol use impairs not only gut and liver functions, but also multi-organ interactions, leading to persistent systemic inflammation and ultimately, to organ damage. The study of these interactions may provide potential new targets for therapeutic intervention.Chronic inflammation is often associated with alcoholrelated medical conditions. The key inducer of such inflammation, and also the best understood, is gut microflora-derived lipopolysaccharide (LPS). Alcohol can significantly increase the translocation of LPS from the gut. In healthy individuals, the adverse effects of LPS are kept in check by the actions and interactions of multiple organs. The liver plays a central role in detoxifying LPS and producing a balanced cytokine milieu. The central nervous syst...

关 键 词：Chronic alcohol use Chronic inflammation Li- popolysaccharides Pro-inflammatory and anti-inflammatory cytokines Kupffer cells MONOCYTES Tumor necrosis factor α INTERLEUKIN-10 NEUROENDOCRINE Hypothalamo-pituitary-adrenal axis GLUCOCORTICOID 

分 类 号：R363[医药卫生—病理学]