Molecular regulation of vasculogenic mimicry in tumors and potential tumor-target therapy  

作　　者：Yue-Zu Fan   Wei Sun 

出　　处：《World Journal of Gastrointestinal Surgery》2010年第4期117-127,共11页世界胃肠外科杂志（英文版）（电子版）

基　　金：Supported by A grant from the National Nature Science Foundation of China,No. 30672073

摘　　要："Vasculogenic mimicry(VM)",is a term that describes the unique ability of highly aggressive tumor cells to express a multipotent,stem cell-like phenotype,and form a pattern of vasculogenic-like networks in threedimensional culture.As an angiogenesis-independent pathway,VM and/or periodic acid-schiff-positive patterns are associated with poor prognosis in tumor patients.Moreover,VM is resistant to angiogenesis inhibitors.Here,we will review the advances in research on biochemical and molecular signaling pathways of VM in tumors and on potential anti-VM therapy strategy.“Vasculogenic mimicry (VM)”, is a term that describes the unique ability of highly aggressive tumor cells to express a multipotent, stem cell-like phenotype, and form a pattern of vasculogenic-like networks in three-dimensional culture. As an angiogenesis-independent pathway, VM and/or periodic acid-schiff-positive patterns are associated with poor prognosis in tumor patients. Moreover, VM is resistant to angiogenesis inhibitors. Here, we will review the advances in research on biochemical and molecular signaling pathways of VM in tumors and on potential anti-VM therapy strategy.

关 键 词：Tumor-target therapy SIGNALING PATHWAYS High AGGRESSIVE TUMOR Molecular regulation Prognosis Vasculogenic MIMICRY 

分 类 号：R730.5[医药卫生—肿瘤]