Cardiovascular and metabolic effects of Berberine  

作　　者：Flora Affuso Valentina Mercurio Valeria Fazio Serafino Fazio 

机构地区：[1]Department of Internal Medicine,Cardiovascular and Immunologic Sciences,University of Naples Federico Ⅱ School of Medicine,Via S.Pansini

出　　处：《World Journal of Cardiology》2010年第4期71-77,共7页世界心脏病学杂志（英文版）（电子版）

摘　　要：Berberine(BBR) is a natural alkaloid isolated from the Coptis Chinensis.While this plant has been used in Ay-urvedic and Chinese medicine for more than 2500 years,interest in its effects in metabolic and cardiovascular disease has been growing in the Western world in the last decade.Many papers have been published in these years reporting beneficial effects in carbohydrate and lip-id metabolism,endothelial function and the cardiovascu-lar system.In this review,we report a detailed analysis of the scientific literature regarding this topic,describing the effects and the underlying mechanisms of BBR on carbohydrate and lipid metabolism,endothelial function and the cardiovascular system.Berberine (BBR) is a natural alkaloid isolated from the Coptis Chinensis. While this plant has been used in Ayurvedic and Chinese medicine for more than 2500 years, interest in its effects in metabolic and cardiovascular disease has been growing in the Western world in the last decade. Many papers have been published in these years reporting beneficial effects in carbohydrate and lipid metabolism, endothelial function and the cardiovascular system. In this review, we report a detailed analysis of the scientific literature regarding this topic, describing the effects and the underlying mechanisms of BBR on carbohydrate and lipid metabolism, endothelial function and the cardiovascular system.

关 键 词：Metabolic syndrome BERBERINE ADENOSINE MONOPHOSPHATE KINASE Insulin resistance Hyperlipid-emia ENDOTHELIAL function 

分 类 号：R54[医药卫生—心血管疾病]