Transient elevation of hepatic enzymes in volunteers after intake of alcohol  

出　　处：《Hepatobiliary & Pancreatic Diseases International》2006年第1期52-55,共4页国际肝胆胰疾病杂志（英文版）

摘　　要：BACKGROUND: In the organs that mediate alcohol effects on the human body and its health, the liver plays a particular important role. This study was designed to detect the changes of hepatic enzymes after alcohol intake and evaluate the corresponding damage to the human body. METHODS: Fifteen volunteers were included according to the criteria. After the intake of 80g ethanol containing beverage, alcohol levels were detected and blood samples were collected at 0.5-to 3-hour interval to detect the levels of hepatic enzymes simultaneously. RESULTS: After the intake of 80g ethanol, various symptoms occurred in volunteers while the concentration of blood alcohol peaked at 1 hour and normalized within 24 hours. The ratio of alanine aminotransferase (ALT) to aspartate aminotransferase (AST) increased significantly when the venous alcoholic concentration increased from 0g/L to 1.2g/L and the levels of alkaline phosphatase (ALP) and gamma-glutamyl transpeptidase(γ-GT) were elevated when the alcoholic concentration reached 0.4g/L. No significant changes were noticed in ALT, AST or cholinesterase (CHE). CONCLUSION: Acute alcohol intoxication may cause the changes of hepatic enzymes and prove the existence of reversible hepatic injury.

关 键 词：liver ALCOHOL injury ALANINE AMINOTRANSFERASE ASPARTATE AMINOTRANSFERASE alkaline phosphatase gamma-glutamyl TRANSPEPTIDASE human 

分 类 号：R575[医药卫生—消化系统]