From control to eradication of malaria:the end of being stuck in second gear?  

作　　者：Khadjavi Amina Giribaldi Giuliana Prato Mauro 

机构地区：[1]Department of Genetics,Biology and Biochemistry,University of Torino Medical School,10126,Torino,Italy

出　　处：《Asian Pacific Journal of Tropical Medicine》2010年第5期412-420,共9页亚太热带医药杂志（英文版）

基　　金：supported by the Compagnia di San Paolo-IMI grants to MP in the context of the Italian Malaria Network

摘　　要：More than 2 billion people are at risk of malaria,which primarily affects poor populations in tropical and subtropical areas,including Southern Asia.As malaria incidence has been reduced strongly in some parts of endemic regions by combinations of interventions,including artemisinin-based therapies and insecticide-treated bed nets,a new goal has been established recently by charity foundations which support research on malaria:the worldwide eradication of the pathology.Doing away with control approaches which have been applied for the last 50 years and more focus on elimination objectives will deeply change priorities in the area of malaria treatment,chemoprevention,vector control,vaccine research and health system assessment.In this review,actual knowledge on pathogenesis and pharmacology is discussed,and new drugs, vaccines and insecticides are described.More than 2 billion people are at risk of malaria,which primarily affects poor populations in tropical and subtropical areas,including Southern Asia.As malaria incidence has been reduced strongly in some parts of endemic regions by combinations of interventions,including artemisinin-based therapies and insecticide-treated bed nets,a new goal has been established recently by charity foundations which support research on malaria:the worldwide eradication of the pathology.Doing away with control approaches which have been applied for the last 50 years and more focus on elimination objectives will deeply change priorities in the area of malaria treatment,chemoprevention,vector control,vaccine research and health system assessment.In this review,actual knowledge on pathogenesis and pharmacology is discussed,and new drugs, vaccines and insecticides are described.

关 键 词：MALARIA Plasmodium FALCIPARUM Anopheles mosquito ANTIMALARIAL drugs Vaccine Vector CONTROL HEMOZOIN Matrix METALLOPROTEINASES 

分 类 号：R531.3[医药卫生—内科学]