Chronic morphine treatment decreases acoustic startle response and prepulse inhibition in rats  

作　　者：MENG ZhiQiang1,3, ZHOU DongMing1,2, WANG JianHong1 & MA YuanYe1,2 1State Key Laboratory of Brain and Cognitive Science, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 2State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China 3Graduate University of Chinese Academy of Sciences, Beijing 100049, China 

出　　处：《Science China(Life Sciences)》2010年第11期1356-1360,共5页中国科学（生命科学英文版）

基　　金：supported by the National Natural Science Foundation of China (Grant Nos.30470553, 30770700 and 30530270);National High-Tech Research and Development Program of China (Grant No. O7013810);Major State Basic Research Development Program of China (Grant Nos.2005CB522803 and 2007CB947703);Yunnan Science and Technology Program (Grant No.2006PT08-2)

摘　　要：The reward-related effects of addictive drugs primarily act via the dopamine system, which also plays an important role in sensorimotor gating. The mesolimbic dopamine system is the common pathway of drug addiction and sensorimotor gating. However, the way in which addictive drugs affect sensorimotor gating is currently unclear. In previous studies, we examined the effects of morphine treatment on sensory gating in the hippocampus. The present study investigated the effects of morphine on sensorimotor gating in rats during chronic morphine treatment and withdrawal. Rats were examined during treatment with morphine for 10 successive days, followed by a withdrawal period. Acoustic startle responses to a single startle stimulus (115 dB SPL) and prepulse inhibition responses were recorded. The results showed that acoustic startle responses were attenuated during morphine treatment, but not during withdrawal. PPI was impaired in the last 2 morphine treatment days, but returned to a normal level during withdrawal.The reward-related effects of addictive drugs primarily act via the dopamine system, which also plays an important role in sensorimotor gating. The mesolimbic dopamine system is the common pathway of drug addiction and sensorimotor gating. However, the way in which addictive drugs affect sensorimotor gating is currently unclear. In previous studies, we examined the effects of morphine treatment on sensory gating in the hippocampus. The present study investigated the effects of morphine on sensorimotor gating in rats during chronic morphine treatment and withdrawal. Rats were examined during treatment with morphine for 10 successive days, followed by a withdrawal period. Acoustic startle responses to a single startle stimulus (115 dB SPL) and prepulse inhibition responses were recorded. The results showed that acoustic startle responses were attenuated during morphine treatment, but not during withdrawal. PPI was impaired in the last 2 morphine treatment days, but returned to a normal level during withdrawal.

关 键 词：MORPHINE TREATMENT SENSORIMOTOR gating STARTLE response PREPULSE inhibition 

分 类 号：R965[医药卫生—药理学]