Fulminant gastrointestinal graft-versus-host disease concomitant with cytomegalovirus infection:Case report and literature review  

作　　者：Hidetaka Okubo Naoyoshi Nagata Naomi Uemura 

机构地区：[1]Department of Gastroenterology and Hepatology,National Center for Global Health and Medicine,Tokyo 162-8655,Japan [2]Department of Gastroenterology and Hepatology,Kohnodai Hospital,Ichikawa 272-0827,Chiba,Japan

出　　处：《World Journal of Gastroenterology》2013年第4期597-603,共7页世界胃肠病学杂志（英文版）

基　　金：Supported by Grant from the National Center for Global Health and Medicine

摘　　要：Here,we report a case of fulminant gastrointestinal graft-versus-host disease(GI-GVHD) with cytomegalovirus(CMV) infection in 44-year-old woman.Despite the difficulties associated with the treatment of GIGVHD and GI-CMV disease,the mucosal findings and the clinical course showed marked improvements during long-term clinical observation.The endoscopic findings were remarkable,with diffuse sloughing mucosa in the stomach and highly active inflammation and deep discrete ulcers throughout the colon.Changes in the CMV quantitative polymerase chain reaction results were correlated with the endoscopic mucosal findings and were useful for assessing the efficacy of the treatment.Although a definite diagnosis of GI-GVHD is generally made by endoscopy with biopsy,the gross appearance of this disease can vary depending on the endoscopy.In this paper,we also conduct a literature review of patients with GI-GVHD.Here, we report a case of fulminant gastrointestinal graft-versus-host disease (GI-GVHD) with cytomegalovirus (CMV) infection in 44-year-old woman. Despite the difficulties associated with the treatment of GI-GVHD and GI-CMV disease, the mucosal findings and the clinical course showed marked improvements during long-term clinical observation. The endoscopic findings were remarkable, with diffuse sloughing mucosa in the stomach and highly active inflammation and deep discrete ulcers throughout the colon. Changes in the CMV quantitative polymerase chain reaction results were correlated with the endoscopic mucosal findings and were useful for assessing the efficacy of the treatment. Although a definite diagnosis of GI-GVHD is generally made by endoscopy with biopsy, the gross appearance of this disease can vary depending on the endoscopy. In this paper, we also conduct a literature review of patients with GI-GVHD.

关 键 词：Acute GASTROINTESTINAL GRAFT-VERSUS-HOST DISEASE ALLOGENIC STEM-CELL transplantation Cytomegalovirus GASTROINTESTINAL DISEASE Cytomegaloviruspolymerase chain reaction Endoscopy 

分 类 号：R57[医药卫生—消化系统]