Chemokines,chemokine receptors and the gastrointestinal system  

作　　者：Hiroshi Miyazaki Kazuaki Takabe W Andrew Yeudall 

机构地区：[1]Department of Biochemistry and Molecular Biology,Virginia Commonwealth University,Richmond,VA 23298,United States [2]Philips Institute of Oral and Craniofacial Molecular Biology,Virginia Commonwealth University,Richmond,VA 23298,United States [3]Massey Cancer Center,Virginia Commonwealth University,Richmond,VA 23298,United States [4]Department of Biochemistry and Molecular Biology,Virginia Commonwealth University,Richmond,VA 23298,United State [5]Department of Surgery,Virginia Commonwealth University,Richmond,VA 23298,United Statess

出　　处：《World Journal of Gastroenterology》2013年第19期2847-2863,共17页世界胃肠病学杂志（英文版）

摘　　要：The biological properties of tumor cells are known to be regulated by a multitude of cytokines and growth factors,which include epidermal growth factor receptor agonists and members of the transforming growth factor β family.Furthermore,the recent explosion of research in the field of chemokine function as mediators of tumor progression has led to the possibility that these small,immunomodulatory proteins also play key roles in carcinogenesis and may,therefore,be potential targets for novel therapeutic approaches.In this review,we will summarize recently reported findings in chemokine biology with a focus on the gastrointestinal tract.The biological properties of tumor cells are known to be regulated by a multitude of cytokines and growth factors, which include epidermal growth factor receptor agonists and members of the transforming growth factor β family. Furthermore, the recent explosion of research in the field of chemokine function as mediators of tumor progression has led to the possibility that these small, immunomodulatory proteins also play key roles in carcinogenesis and may, therefore, be potential targets for novel therapeutic approaches. In this review, we will summarize recently reported findings in chemokine biology with a focus on the gastrointestinal tract.

关 键 词：CHEMOKINE Receptor Signal TRANSDUCTION Tumor PROGRESSION Targeted THERAPEUTICS DIGESTIVE system Cancer 

分 类 号：R57[医药卫生—消化系统]