Up-regulation of NKG2D ligand ULBP2 by matrine in K562 cells and the underlying molecular mechanisms  

作　　者：马玲娣 

机构地区：[1]Dept Hematol,1st Affili Hosp Nanjing Med Univ

出　　处：《China Medical Abstracts(Internal Medicine)》2014年第3期187-188,共2页中国医学文摘（内科学分册（英文版）

摘　　要：Objective To probe matrine acting on natural killer cell(NK)activating receptor NKG2D ligands expression in CML cell line K562 and its underlying molecular mechanism.Methods The expression of NKG2D ligands(major histocompatibility complex class I chain-related molecule A or B(MICA/B),UL16-binding proteins(ULBP)1,2,and 3 on K562 cells were analyzed before and after treated with matrine by FCM.The cytotoxic sensitivity of K562 to NK cell was detected by FCM

关 键 词：MATRINE activating CYTOTOXIC UNDERLYING KILLER killed acting UNTREATED transduction inhibited 

分 类 号：R346[医药卫生—基础医学]