Sphingosine-1-phosphate signaling in vasculogenesis and angiogenesis  

作　　者：Kelley M Argraves Brent A Wilkerson W Scott Argraves 

机构地区：[1]Department of Regenerative Medicine and Cell Biology,Medical University of South Carolina,173 Ashley Avenue Charleston,SC 29425,United States

出　　处：《World Journal of Biological Chemistry》2010年第10期291-297,共7页世界生物化学杂志（英文版）（电子版）

基　　金：Supported by Grants from the United States Public Health Service/National Institutes of Health, No. HL080404, HL094883 (Argraves KM) and HL061873, HL095067 (Argraves WS);NIH Training Grant to Improve Cardiovascular Therapies HL007260 (Wilkerson BA);American Heart Association 10PRE3910006 (Wilkerson BA)

摘　　要：Blood vessels either form de novo through the process of vasculogenesis or through angiogenesis that involves the sprouting and proliferation of endothelial cells in pre-existing blood vessels. A complex interactive network of signaling cascades downstream from at least three of the nine known G-protein-coupled sphingosine-1-phosphate (S1P) receptors act as a prime effector of neovascularization that occurs in embryonic development and in association with various pathologies. This review focuses on the current knowledge of the roles of S1P signaling in vasculogenesis and angiogenesis, with particular emphasis on vascular cell adhesion and motility responses.Blood vessels either form de novo through the process of vasculogenesis or through angiogenesis that involves the sprouting and proliferation of endothelial cells in pre-existing blood vessels. A complex interactive network of signaling cascades downstream from at least three of the nine known G-protein-coupled sphingosine-1-phosphate (S1P) receptors act as a prime effector of neovascularization that occurs in embryonic development and in association with various pathologies. This review focuses on the current knowledge of the roles of S1P signaling in vasculogenesis and angiogenesis, with particular emphasis on vascular cell adhesion and motility responses.

关 键 词：Sphingosine-1-phosphate VASCULOGENESIS ANGIOGENESIS G-protein-coupled receptors ENDOTHELIUM 

分 类 号：R363[医药卫生—病理学]