化妆品防腐剂抑菌和微生物污染关系的研究  

Investigation of relation between bacteriostasis of antiseptic and microorganism pollution of cosmetics

作　　者：许雅[1] 曾转萍[1] 吴宪毅[1] 陈榕[1] 蔡旭玲[1] 

机构地区：[1]广东药学院流行病学教研室,广州510224

出　　处：《中国卫生检验杂志》2005年第10期1201-1203,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的:了解化妆品防腐剂抑菌和微生物污染之间关系。方法:在化妆品使用前、使用14 d、使用28 d 3个使用时段,用纸片法对60份化妆品进行防腐剂抑菌效果检测,按《化妆品微生物标准检验检测方法》进行微生物污染情况检测。结果:防腐剂对金黄色葡萄球菌的抑菌效果优于大肠杆菌(P<0.05);3个使用时段,对金黄色葡萄球菌不明显抑菌的分别为56.7%、85.0%、86.4%,部分抑菌的分别为31.7%、8.3%、6.8%,明显抑菌的分别为11.6%、6.7%、6.8%;对大肠杆菌不明显抑菌的分别为91.7%、95.0%、100.0%,部分抑菌的分别为8.3%、5.0%、0.0%,明显抑菌的均为0.0%;3个使用时段的细菌总数超标率分别为6.7%、45.0%、66.1%,金黄色葡萄球菌检出率分别为0.0%、1.7%、3.4%,粪大肠菌群检出率分别为0.0%、1.7%、1.7%,铜绿假单胞菌未检出;随着使用时间的增长,化妆品防腐剂抑菌效果则呈减弱趋势(P<0.05),而细菌总数超标率呈增加趋势(P<0.05)。结论:化妆品防腐剂抑菌的效果与微生物受污染的程度有着密切的联系。Objective：To evaluate the relationship between the cosmetic microorganism pollution and the antiseptic bacteriostasis. Methods ： Samples were collected in 3 stages, which were original, used 14 days and 28 days. Furthermore, disc - paper assay was used to examine bacteriostasis effect of antiseptic and a standard method stated in ‘Hygienic Standard for Cosmetics’ was used to examine the microorganism pollution of 60 cosmetics. Results： Iri three using periods, the rates of antiseptic of S. aureus in 3 different bacteriostasis effects which were non -obvious control, partly control and obvious control were 56. 7% ,85.0%, 86.4% ;31.7% ,8.3% ,6.8% ;11.6% ,6. 7% ,6. 8% respectively. To E. coli, the rates were 91.7% ,95.0% ,100. 0% ; 8.3% , 5.0% ,0. 0% ; 0.0% ,0. 0% ,0. 0% respectively. Furthermore,the overstandard rates of the total counts of bacteria were 6.7% , 45.0% and 66. 1%. The positive rates of S. aureus were 0. 0% , 1.7% ,3.4% and the positive rates of fecal coliform were 0. 0% , 1.7% ,1.7%. Moreover, the longer cosmetics were used,the more of bacteria would be detected（P 〈0. 05）. However, the effect of the bacteriostasis of antiseptic was decreased by time. Conclusion：There are closely relationship between the microorganism pollution of cosmetic and the bacteriostasis of antiseptic.

关 键 词：化妆品 防腐剂 抑菌 微生物污染 

分 类 号：TS974.1[轻工技术与工程]