An investigation of the antinociceptive effects of Riluzole in hyperal gesia models of mice  

作　　者：Xiaoping Xia Zhenliang Ma Yinming Zeng 

机构地区：[1]Nanjing University Medical School affiliated Drum Tower Hospital, Nanjing 210008, China [2]Jiangsu Institute of Anesthesiology, Jiangsu Key Laboratory of Anesthesiology,Xuzhou Medical College, Xuzhou 221002, China

出　　处：《Journal of Nanjing Medical University》2006年第3期172-175,共4页南京医科大学学报（英文版）

基　　金：Key Laboratory Foundation of Jiangsu Province Department of Health(WK200501)

摘　　要：Objective： To investigate the antinociceptive effects of Riluzole administered intraperitoneally in three hyperalgesia model of mice. Methods： Antinociceptive tests in C57BL mice were investigated with formalin test,acetic acid induced writhing test and tail-immersion test. The effects of intraperitoneally Riluzole 2 mg/kg ,4 mg/kg and 8 mg/kg on the pain threshold were observed. Result： We found that i.p. treatment with Riluzole （4 mg/kg and 8 mg/kg） blocked the second phase flinching behavior compared with vehicle （P 〈 0.05）, but not during the first phase in the formalin test. In addition to the formalin test, Riluzole at different dose （from 2 to 8 mg/kg） attenuated acetic acid induced writhing response when compared to vehicle group （P 〈 0.05）. In the tail-immersion test, Riluzole at the highest dose （8 mg/kg） caused significant increase in tail flick response latency as compared to vehicle animals or compared with Baseline （P 〈 0.05）. Conclusion： Our results suggest that glutamate release inhibitor Riluzole can attenuate nociceptive behavior and has differrent antinociceptive characteristic according to the various pain models.Objective： To investigate the antinociceptive effects of Riluzole administered intraperitoneally in three hyperalgesia model of mice. Methods： Antinociceptive tests in C57BL mice were investigated with formalin test,acetic acid induced writhing test and tail-immersion test. The effects of intraperitoneally Riluzole 2 mg/kg ,4 mg/kg and 8 mg/kg on the pain threshold were observed. Result： We found that i.p. treatment with Riluzole （4 mg/kg and 8 mg/kg） blocked the second phase flinching behavior compared with vehicle （P 〈 0.05）, but not during the first phase in the formalin test. In addition to the formalin test, Riluzole at different dose （from 2 to 8 mg/kg） attenuated acetic acid induced writhing response when compared to vehicle group （P 〈 0.05）. In the tail-immersion test, Riluzole at the highest dose （8 mg/kg） caused significant increase in tail flick response latency as compared to vehicle animals or compared with Baseline （P 〈 0.05）. Conclusion： Our results suggest that glutamate release inhibitor Riluzole can attenuate nociceptive behavior and has differrent antinociceptive characteristic according to the various pain models.

关 键 词：RILUZOLE Formalin test INFLAMMATION PAIN GLUTAMATE NOCICEPTION 

分 类 号：R441[医药卫生—诊断学]