利用手性N—苄基—2—羟基蒎烷—3—酮亚胺合成光学活性α—取代苄胺  

Asymmetric Synthesis of Chiral α-Substituted Benzylamines via Pinanone Ketimine

作　　者：陈元伟[1] 宓爱巧[1] 肖勋[1] 蒋耀忠[1] 

机构地区：[1]中国科学院成都有机化学研究所

出　　处：《化学学报》1990年第11期1131-1135,共5页Acta Chimica Sinica

基　　金：国家自然科学基金

摘　　要：本文以2-羟基蒎烷-3-酮(2)为手性助剂,与苄胺缩合得到的酮亚胺为中间体,经去质子化、不对称烷基化、转胺反应得到光学活性α-取代苄胺(5),光学纯度为93.9—99.9％;同时2可以肟的形式回收。An asymmetric alkylation of benzylamine was realized by using 2-hydroxypinan-3-one as a chiral auxiliary to form a chiral ketimine and followed by alkylation and removal of the auxiliary. The optical purity of α-substituted benzylamine thus obtained ranged from 93.9 to 99.9%. The chiral auxiliary 2-hydroxypinan-3-one was recovered as its oxime.

关 键 词：取代苄胺 手性胺 合成 蒎烷酮亚胺 

分 类 号：O625.631[理学—有机化学]