The effects of the synthetic nocistatin on blood vessel activities  

作　　者：Qiang Chen Yong Chen Lixiang Chen Dingjian Yang Shouliang Dong Rui Wang 

机构地区：[1]Lanzhou Univ, Sch Life Sci, Dept Biochem & Mol Biol, Lanzhou 730000, Peoples R China

出　　处：《Chinese Science Bulletin》2001年第8期675-678,共4页

基　　金：the National NaturalScience Foundation of China (Grant No. 29972016) and the Natural Science Foundation of Gansu Province (Grant No. ZS 991-A23-056).

摘　　要：Nocistatin was synthesized by the solid-phase peptide synthesis method. Its effects on rat systemic arterial pressure; rat hindquarter vascular bed resistance; tension of rabbit pectoral, abdominal, femoral aorta muscle strips without endothelium; and nociceptin induced decreases of rat systemic arterial pressure were determined. The results showed that nocistatin can increase the systemic arterial pressure, increase the hindquarter vascular bed resistance and induce the contraction significantly of abdominal, femoral aorta muscle strips without endotheiium; it has no significant effect on tension of pectoral aorta muscle strips, it cannot antagonize significantly the decrease of rat systemic arterial pressure induced by nociceptin. These results suggest that nocistatin has some important effects on blood vessel activities.Nocistatin was synthesized by the solid-phase peptide synthesis method. Its effects on rat systemic arterial pressure; rat hindquarter vascular bed resistance; tension of rabbit pectoral, abdominal, femoral aorta muscle strips without endothelium; and nociceptin induced decreases of rat systemic arterial pressure were determined. The results showed that nocistatin can increase the systemic arterial pressure, increase the hindquarter vascular bed resistance and induce the contraction significantly of abdominal, femoral aorta muscle strips without endothelium; it has no significant effect on tension of pectoral aorta muscle strips, it cannot antagonize significantly the decrease of rat systemic arterial pressure induced by nociceptin. These results suggest that nocistatin has some important effects on blood vessel activities.

关 键 词：SOLID-PHASE POLYPEPTIDE synthesis NOCISTATIN NOCICEPTIN SYSTEMIC BLOOD pressure hindquarter vascular bed resistance BLOOD vessel muscle strip. 

分 类 号：Q592[生物学—生物化学]