Supported by The Deutsche Forschungsgemeinschaft(STO 645/2-1 to Storr M and YU132/2-1 to Yuece B);the Society of Gastroenterology in Bavaria(to Storr M);the Frderprogramm für Forschung und Lehre of the Ludwig Maximilians University Munich to Yuece B;the University of Calgary Research Grant Committee(to Storr M);the Iuventus Plus program of the Polish Ministry of Science and Higher Education(#0107/IP1/2013/72 to Fichna J);the grants from the Medical University of Lodz(#503/1-156-04/503-01 to Fichna J);National Science Centre(#UMO-2013/11/B/NZ7/01301 to Fichna J)
AIM: To study the effect of the opioid-receptor like-1(ORL1) agonist nociceptin on gastrointestinal(GI)myenteric neurotransmission and motility. METHODS: Reverse transcriptase- polymerase chain reaction and immunohist...
Aim: To investigate the role of hypothalamus nociceptin/orphanin FQ (OFQ) and its endogenous receptor, the opioid receptor-likel receptor (ORL1 receptor) in the estrus cycle of female rats. Method: Radioimmunoas...
AIM: To demonstrate the change and effect of nodceptin/orphanin FQ in the colon of rats with cathartic colon. METHODS: The cathartic colon model was established by feeding rats rhubarb for 3 mo, the changes of colon...
AIM: The utility of serum alpha-fetoprotein (α-FP) in the detection of hepatocellular carcinoma (HCC) is questionable. Very high circulating levels of nociceptin/ orphanin FQ (N/OFQ), a ligand for a novel opio...
Aim: To investigate effect of the nociceptin/orphanin FQ (OFQ) on hypothalamus gonadotropin-releasing hormone (GnRH) release in ovariectomized (OVX) rats. Methods: GnRH radioimmunoassay (RIA) was used to stu...
AIM:The heptadecapeptide nociceptin alias orphanin FQ is the endogenous agonist of opioid receptor-likel receptor. It is involved in modulation of pain and cognition.High blood level was reported in patients with acut...
AIM:Although liver cirrhosis is a predisposing factor for hepatocellular carcinoma (HCC),relatively few reports are available on HCC in primary biliary cirrhosis.High plasma nociceptin (N/OFQ) level has been shown in ...
Project supported by the National Natural Science Foundation of China, № 39870915.
AIM: To explore the neuro-immune modulatory effect of orphanin FQ/nociceptin (OFQ) and opioid receptor like 1 (ORL1) receptor on the traumatic rats. METHODS: The quantitative method of immuno-cytochemistry and in situ...
Nociceptin, or orphanin FQ, is a 17 amino-acid peptide which is a newly discovered endogenous ligand for the opioid-like G-protein coupled receptor, ORLI, and suggested to participate in modulating nociceptive transmi...