NOCICEPTIN

作品数:19被引量:22H指数:3
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相关领域:医药卫生更多>>
相关作者:方理本吴茵杨秋火曹阳蒋华良更多>>
相关机构:浙江大学台湾大学中国科学院苏州大学更多>>
相关期刊:《山西医科大学学报》《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》《World Journal of Gastrointestinal Pharmacology and Therapeutics》更多>>
相关基金:国家自然科学基金更多>>
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Antagonism of endogenous nociceptin/orphanin FQ inhibits infarction associated ventricular arrhythmias via PKC dependent mechanism in rats
《中国循环杂志》2016年第z1期-,共1页Yi Han Zheng Guo 
Nociceptin effect on intestinal motility depends on opioidreceptor like-1 receptors and nitric oxide synthase colocalization被引量:2
《World Journal of Gastrointestinal Pharmacology and Therapeutics》2015年第3期73-83,共11页Andrei Sibaev Jakub Fichna Dieter Saur Birol Yuece Jean-Pierre Timmermans Martin Storr 
Supported by The Deutsche Forschungsgemeinschaft(STO 645/2-1 to Storr M and YU132/2-1 to Yuece B);the Society of Gastroenterology in Bavaria(to Storr M);the Frderprogramm für Forschung und Lehre of the Ludwig Maximilians University Munich to Yuece B;the University of Calgary Research Grant Committee(to Storr M);the Iuventus Plus program of the Polish Ministry of Science and Higher Education(#0107/IP1/2013/72 to Fichna J);the grants from the Medical University of Lodz(#503/1-156-04/503-01 to Fichna J);National Science Centre(#UMO-2013/11/B/NZ7/01301 to Fichna J)
AIM: To study the effect of the opioid-receptor like-1(ORL1) agonist nociceptin on gastrointestinal(GI)myenteric neurotransmission and motility. METHODS: Reverse transcriptase- polymerase chain reaction and immunohist...
关键词:NOCICEPTIN Gastrointestinal TRANSIT Opioidreceptor like-1 ELECTROPHYSIOLOGY Expression 
Role of hypothalamus nociceptin/orphanin FQ in pre-ovulatory luteinizing hormone surge of estrogen and progesterone-primed,ovariectomized rats被引量:1
《Acta Pharmacologica Sinica》2007年第8期1189-1197,共9页Xiao-fei AN Jiang-yi YU Yi FENG Bo-ying CHEN Su-lin ZHANG 
Aim: To investigate the role of hypothalamus nociceptin/orphanin FQ (OFQ) and its endogenous receptor, the opioid receptor-likel receptor (ORL1 receptor) in the estrus cycle of female rats. Method: Radioimmunoas...
关键词:orphanin FQ opioid receptor-like 1 receptor luteinizing hormone estrus cycle HYPOTHALAMUS 
Effects of nociceptin/orphanin FQ on rats with cathartic colon被引量:7
《World Journal of Gastroenterology》2007年第1期141-145,共5页Hai-Yan Li Xiang Yan Quan-Lai Xue Yong-Ning Zhou Yan Gao Rui Wang Yong-Ming Liu Jun-Tao Ran 
AIM: To demonstrate the change and effect of nodceptin/orphanin FQ in the colon of rats with cathartic colon. METHODS: The cathartic colon model was established by feeding rats rhubarb for 3 mo, the changes of colon...
关键词:GASTROENTEROLOGY 
Low utility of plasma Nociceptin/orphanin FQ in the diagnosis of hepatocellular carcinoma
《World Journal of Gastroenterology》2006年第29期4716-4720,共5页Aldo Spadaro Antonino Ajello Carmelo Luigiano Carmela Morace Maria Letizia Resta Grazia Berlinghieri Salvatore Campo Claudio Scisca Angela Alibrandi Graziella D'arrigo Nunziata Alessi Oscar Ferraù Maria Antonietta Freni 
AIM: The utility of serum alpha-fetoprotein (α-FP) in the detection of hepatocellular carcinoma (HCC) is questionable. Very high circulating levels of nociceptin/ orphanin FQ (N/OFQ), a ligand for a novel opio...
关键词:Hepatocellular carcinoma Nociceptin/orphanin FQ Liver cirrhosis ALPHA-FETOPROTEIN 
Involvement of nociceptin/orphanin FQ in release of hypothalamic GnRH mediated by ORL1 receptor in ovariectomized rats被引量:2
《Acta Pharmacologica Sinica》2005年第9期1039-1044,共6页Xiao-fei AN Hai-ping CHEN Shu-lan MA Yi FENG Jun-wei HAO Bo-ying CHEN 
Aim: To investigate effect of the nociceptin/orphanin FQ (OFQ) on hypothalamus gonadotropin-releasing hormone (GnRH) release in ovariectomized (OVX) rats. Methods: GnRH radioimmunoassay (RIA) was used to stu...
关键词:NOCICEPTIN ORL1 receptor GONADORELIN HYPOTHALAMUS 
Increased nociceptin/orphanin FQ plasma levels in hepatocellular carcinoma被引量:5
《World Journal of Gastroenterology》2004年第1期42-45,共4页FerencSzalay AndreaHorvath PeterL.Lakatos AnikoFolhoffer KingaDunkel DalmaHegedus KornéliaTekes MónikaBHantos 
AIM:The heptadecapeptide nociceptin alias orphanin FQ is the endogenous agonist of opioid receptor-likel receptor. It is involved in modulation of pain and cognition.High blood level was reported in patients with acut...
关键词:ADULT Aged Aged  80 and over Carcinoma  Hepatocellular FEMALE Humans Liver Cirrhosis Liver Neoplasms Male Middle Aged Opioid Peptides RADIOIMMUNOASSAY 
Rising plasma nociceptin level during development of HCC:A case report被引量:1
《World Journal of Gastroenterology》2004年第1期152-154,共3页AndreaHorvath AnikoFolhoffer PeterLaszloLakatos FerencSzalay JuditHalász GyorgyIllyés ZsuzsaSchaff Kornelia Tekes Monika Beatrix Hantos 
AIM:Although liver cirrhosis is a predisposing factor for hepatocellular carcinoma (HCC),relatively few reports are available on HCC in primary biliary cirrhosis.High plasma nociceptin (N/OFQ) level has been shown in ...
关键词:Carcinoma  Hepatocellular Female Humans Liver Cirrhosis  Biliary Liver Neoplasms Middle Aged Opioid Peptides Tumor Markers  Biological 
Immunomodulatory activity of orphanin FQ/nociceptin on traumatic rats
《Acta Pharmacologica Sinica》2002年第4期343-348,共6页肇晖 吴根诚 曹小定 
Project supported by the National Natural Science Foundation of China, № 39870915.
AIM: To explore the neuro-immune modulatory effect of orphanin FQ/nociceptin (OFQ) and opioid receptor like 1 (ORL1) receptor on the traumatic rats. METHODS: The quantitative method of immuno-cytochemistry and in situ...
关键词:orphanin PQ INTERLEUKIN-1 tumor necrosis factor MACROPHAGES 
INHIBITORY EFFECT OF NOCICEPTIN ON EXCITATORY BUT NOT INHIBITORY TRANSMISSION IN RAT SPINAL DORSAL HORN NEURONES
《神经解剖学杂志》2001年第B07期110-110,共1页Eiichi KUMAMOTO Hidemasa FURUE Megumu YOSHIMURA 
Nociceptin, or orphanin FQ, is a 17 amino-acid peptide which is a newly discovered endogenous ligand for the opioid-like G-protein coupled receptor, ORLI, and suggested to participate in modulating nociceptive transmi...
关键词:大白鼠 脊髓背角神经 配体 损伤感受素 兴奋传导 抑制作用 SG 
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