Roles of histones and nucleosomes in gene transcription  

作　　者：Baiqu Huang Qinhua Zeng Xiaohui Bi Yuhong Wang Yuxin Li 

机构地区：[1]NE Normal Univ, Inst Cytol & Genet, Changchun 130024, Peoples R China

出　　处：《Chinese Science Bulletin》2001年第3期184-188,共5页

基　　金：Part of the work in this article was supported by the National Natural Science Foundation of China (Grant No. 3997038) ;and the National "973" Basic Research Project (Grant No. G19I99053902).

摘　　要：This article reviews the latest research developments in the field of eukaryotic gene regulation by the structural alterations of chromatin and nucleosomes. The following issues are briefly addressed: (i) nucleosome and histone modifications by both the ATP-dependent remodeling complexes and the histone acetyltransferases and their roles in gene activation; (ii) competitive binding of histones and transcription factors on gene promoters, and transcription repression by nucleosomes; and (iii) influences of linker histone HI on gene regulation. Meanwhile, the significance and impact of these new research progresses, as well as issues worthwhile for further study are commented.This article reviews the latest research developments in the field of eukaryotic gene regulation by the structural alterations of chromatin and nucleosomes. The following issues are briefly addressed: (i) nucleosome and histone modifications by both the ATP-dependent remodeling complexes and the histone acetyltransferases and their roles in gene activation; (ii) competitive binding of histones and transcription factors on gene promoters, and transcription repression by nucleosomes; and (iii) influences of linker histone H1 on gene regulation. Meanwhile, the significance and impact of these new research progresses, as well as issues worthwhile for further study are commented.

关 键 词：HISTONES NUCLEOSOME CHROMATIN REMODELING gene transcription. 

分 类 号：Q75[生物学—分子生物学]