A FACTOR FROM GRANULOSA CELLS CAN STIMULATE OOCYTE TISSUE PLASMINOGEN ACTIVATOR ACTIVITY  

作　　者：刘以训 

机构地区：[1]Laboratory of Reproductive Biology, Institute of Zoology, Academia Sinica, Beijing 100080, PRC

出　　处：《Science China Chemistry》1989年第12期1449-1456,共8页中国科学（化学英文版）

基　　金：This work was supported by the Rockefeller Foundation, National Institutes of Health Research Grant and National Natural Science Foundation of China.

摘　　要：Several studies indicate that substances synthesized by granulosa cells are capableof regulating oocyte activity. We have studied the effect of factors synthesized by gran-ulosa cells on tPA activity of denuded oocytes using a co- culture system. The resultsshow that an FSH- dependent factor(s) synthesized by granulosa cells (but not by theca-interstitial cells) is capable of stimulating tPA activity of denuded oocytes. This findingis important for understanding hormonal regulation of oocyte tPA activity by mediatorssynthesized in granulosa cells.Several studies indicate that substances synthesized by granulosa cells are capable of regulating oocyte activity. We have studied the effect of factors synthesized by gran- ulosa cells on tPA activity of denuded oocytes using a co- culture system. The results show that an FSH- dependent factor(s) synthesized by granulosa cells (but not by theca- interstitial cells) is capable of stimulating tPA activity of denuded oocytes. This finding is important for understanding hormonal regulation of oocyte tPA activity by mediators synthesized in granulosa cells.

关 键 词：GRANULOSA cell SECRETORY FACTOR OOCYTE tissue PLASMINOGEN ACTIVATOR (tPA) 

分 类 号：O6[理学—化学]