富硒轮梗霉与奶醋对小鼠降血脂和抗氧化作用的影响  

Hypolipidemic and Antioxidation Effects of Selenium-enriched Mycelia of Diasporangium sp. or/and Milk Vinegar on Mice

作　　者：管娴月[1] 戴传超[1] 徐玉芬[1] 朱明[2] 张凯[1] 

机构地区：[1]南京师范大学生命科学学院,江苏省生物多样性与生物技术重点实验室,江苏南京210046 [2]淮海工学院江苏省海洋生物技术重点建设实验室,江苏连云港222005

出　　处：《食品科学》2009年第17期319-323,共5页Food Science

基　　金：“十一五”国家科技支撑计划项目(2006BAD27B09);江苏省海洋生物技术重点建设实验室开放项目(2007HS012)

摘　　要：84只昆明系雄性小鼠,随机均分为7组:普通对照组、高脂对照组、亚硒酸钠组、轮梗霉组、富硒轮梗霉组、奶醋组、奶醋+富硒轮梗霉组,30d后测定小鼠空腹体重量、脏器指数、血脂和抗氧化力指标水平、组织硒含量以及肝脏脂肪酸含量。结果表明:富硒轮梗霉能显著降低高脂血症小鼠的TC、TG和LDL-C,升高HDL-C,降低高脂血症小鼠MDA的水平,提高SOD、GSH-Px活性。富硒轮梗霉与奶醋复配对小鼠各检测指标的影响优于富硒轮梗霉组。亚硒酸钠组中组织硒含量显著高于对照组但低于富硒轮梗霉和奶醋富硒轮梗霉组。富硒轮梗霉组的花生四烯酸含量显著提高,含量为11.94%。富硒轮梗霉能显著提高机体降血脂和抗氧化能力,与奶醋复配后效果仍优于其他组别。For the purpose of providing theoretical references for the development of healthcare foods which can offer cardiovascular protection, the hypolipidemic and antioxidation effects of selenium-enriched mycelia of Diasporangium sp., milk vinegar and selenium-enriched mycelia of Diasporangium sp. plus milk vinegar on mice were investigated. Eighty-four male Kunming mice were randomly divided into control, high fat model, sodium selenite, Diasporangium sp., selenium-enriched Diasporangium sp., milk vinegar and milk vinegar plus selenium-enriched Diasporangium sp. groups. After 30 d feeding stage, the changes in serum lipid, viscera index, antioxidation system level, Se content and fatty acids of liver and body weight were observed. Selenium-enriched mycelia of Diasporangium sp. could significantly reduce low-density lipoprotein cholesterol （LDL-C）, total cholesterol （TC）, triglyceride （TG） and increase high-density lipoprotein cholesterol （HDL-C）. The activities of serum surperoxide dismutase （SOD） and lutathione peroixdase （GSH-Px） in the selenium-enriched Diasporangium sp. group were significantly higher than those in the other groups, and the malondialdehyde （MDA） level was significantly lower. All the measured indexes of mice fed selenium-enriched Diasporangium sp. plus milk vinegar were better than those of mice only fed selenium-enriched Diasporangium sp.. The Se content of the sodium selenite group was significantly higher than that of the control group, but lower than those of the selenium-enriched Diasporangium sp. and the milk vinegar plus selenium-enriched Diasporangium sp. groups. The content of arachidonic acid of the selenium-enriched Diasporangium sp. group reached 11.94%, which was significantly increased. The results showed that selenium-enriched Diasporangium sp. is able to significantly reduce blood lipid and enhance antioxidation function in mice and the combination of it and milk vinegar has much better effects than those of other groups.

关 键 词：硒 奶醋 轮梗霉 降血脂 抗氧化 

分 类 号：Q949.32[生物学—植物学]