白首乌片的食品安全性毒理学研究  

Toxicicological Study of Food Safety of Baishouwu ( Cynanchum Auriculatum Royle ex Wight )

作　　者：陆琮明[1] 张小强[1] 翟成凯[1] 吴良清[1] 蒋兆坤[1] 

机构地区：[1]南京铁道医学院营养与食品卫生学教研室

出　　处：《南京铁道医学院学报》1998年第4期261-263,共3页Journal of Nanjing Railway Medical College

摘　　要：目的：对白首乌进行食品安全性毒理学评价。方法：采用急性毒性试验、Ａｍｅｓ试验、小鼠骨髓微核试验、小鼠精子畸形试验和３０ｄ喂养试验，对白首乌进行食品安全性评价。结果：急性毒性及Ａｍｅｓ试验、小鼠骨髓微核和精子畸形试验结果都呈阴性。３０ｄ喂养试验，含１／１０白首乌片饲料组，试验动物出现了兴奋性增高，易激怒，明显消瘦，体重呈下降趋势，食物利用率低，雌性动物血小板有减少倾向，雄性动物谷草转氨酶（ＡＳＴ）、谷丙转氨酶（ＡＬＴ）有升高倾向；含１／５白首乌片饲料组，动物陆续死亡，有轻度肝细胞颗粒样变性等。结论：白首乌片最大无作用剂量为４ｇ·ｋｇ１，推算到６０ｋｇ体重的人体，一天允许摄入白首乌片２．４ｇ，白首乌不宜作为食品。Objective:The experiment was designed to toxicicologically evaluate the food safety of Baishouwu( Cynanchum auriculatum Royle ex Wight ).Method:The acute toxicity test,micronucleus test of bone marrow cell, sperm shape abnormality test in mice and thirty-days-feeding test in rats were performed.Result:All tests yielded negative results. Manifestation of the group with 1/10 of Baishouwu pieces added in feed weight included excitement arised,easy irritation,obvious emaciation,tendency to decrease in body weight,low utilization ratio,and tendency to decreased in thrombocyte on female animals,tendency to increased in AST and ALT levels on male animals.The animals in the group with 1/10. of Baishouwu pieces added in feed weight died in succession and a granular degeneration of liver cells was found.Conclusion:The maximum no-observed-effect level of Baishouwu pieces on mice is 4g·kg 1 . Infering to a human being with body weight of 60kg, the allowed intake quantity of Baishouwu pieces will be 2.4g and that's why it can not be used as food.

关 键 词：白首乌 食品 安全性 小鼠 WISTAR大鼠 

分 类 号：R155.5[医药卫生—营养与食品卫生学]