左乙拉西坦单药治疗小儿癫痫的自身对照研究  

The study on Levetiracetam monotherapy in children with epilepsy.

作　　者：翟琼香[1,2] 丁健[3] 戴启麟[4] 陈志红[1,2] 郝英[1,2] 郭予雄[1,2] 桂娟[1,2] 张宇昕[1,2] 

机构地区：[1]广东省人民医院 [2]广东省医学科学院儿科广东省神经科学研究所,广州510080 [3]南方医科大学儿科 [4]中山大学附属第一医院神经科

出　　处：《中国神经精神疾病杂志》2010年第6期352-354,共3页Chinese Journal of Nervous and Mental Diseases

基　　金：广东省自然基金项目(编号:7001205);广东省科技计划项目(编号:2009B030801250)

摘　　要：目的研究左乙拉西坦作为单药治疗不同类型癫痫患儿的临床疗效和安全性。方法采用前瞻性研究,对62例不同类型癫痫患儿进行左乙拉西坦单药治疗。左乙拉西坦起始剂量为20 mg/(kg.d),分两次服用,每两周增加10 mg/(kg.d),维持剂量30～40 mg/(kg.d)。稳定期:维持加量期12周,每个月观察1次,以治疗前3个月的发病频率为基础,完成了6个月的观察期,随访6～24个月(平均随访12.8个月),观察发作频率的变化及不良反应。结果 62例入选患儿,完全控制发作38例,占61.3%,显效8例,占12.9%;有效9例,占14.5%;无效4例,占6.5%;加重3例,占4.8%。总有效率为88.7%,两年治疗保留率为72%。左乙拉西坦治疗前后发作频率改变有统计学意义(P<0.005)。结论左乙拉西坦作为单药治疗小儿各型癫痫有良好疗效及安全性。Objective To evaluate the clinical efficacy and safety of levetiracetam monotherapy in children with different types of epilepsies.Methods We prospectively studied 62 cases children with different types of epilepsies receiving Levetiracetam monotherapy.Levetiracetam was administrated at an initial dose of 20 mg/kg twice daily,and the dose was gradually increased by 10 mg/kg daily every two weeks for twelve weeks until reaching maintenance dose of 30-40 mg/kg daily.Patients were monitored closely for 6 month and then followed up for 7 to 24 months with a mean of 12.8 months for the seizure frequency and adverse effects.Results Among total of 62 cases,levetiracetam could achieve complete seizure control in 38 cases（61.3%）,and was significantly effective in 8 cases（12.9%）,effective in 9 cases（14.5%）,ineffective in 4 cases（6.5%） and deleterious in 3 cases（4.8%）.The total effective rate was 88.7% and two-year treatment retention rate was 72%.Conclusions Levetiracetam monotherapy is safe and efficacious for children with various types of epilepsy.

关 键 词：癫痫 左乙拉西坦 治疗 小儿 单药 

分 类 号：R742.1[医药卫生—神经病学与精神病学]