遗传性非息肉病性大肠癌12个家族37例报告  

Hereditary nonpolyposis colorectal cancer :a report of 37 cases in 12 families

作　　者：王振义[1,2,3,4] 尹伯约[1,2,3,4] 闫于悌[1,2,3,4] 丁继勇 褚福成 

机构地区：[1]中国人民解放军第一医院普外科 [2]甘肃省人民医院肛肠科 [3]甘肃省会宁县医院外科 [4]中国人民解放军第一四一医院外科

出　　处：《中华普通外科杂志》1999年第2期133-135,共3页Chinese Journal of General Surgery

摘　　要：目的提高对遗传性非息肉病性大肠癌（ＨＮＰＣＣ）本质的认识。方法对１２个有遗传性非息肉病性大肠癌家族进行了回顾性分析。结果１２家族有３７例大肠癌患者，发病中位年龄为４４８岁，总计大肠癌灶４４处，其中结肠癌占６４％（２８／４４），位于脾曲以近的口侧段结肠内占５２％（２３／４４），大肠多原发癌占１１％（４／３７），有４个家族的子代患其它器官癌（３例胃癌、１例胆囊癌）占３３％（４／１２），全组病例未发现大肠息肉。结论对遗传性非息肉病性大肠癌患者及家族要进行严密监测，以便早期发现，及时治疗。Objective To improve the recognition of the essence of the hereditary nonpolyposis colorectal cancer (HNPCC). Methods A retrospective analysis of 37 HNPCC cases in 12 families was made.Results Among the 12 families 37 persons had colorectal cancer,with a total of 44 foci.The average age of the cancer onset was 44 8 years (from 24 to 64).Four offsprings in 4 families also suffered cancer in other organs,i.e. stomach cancer in 3 cases and gallbladder cancer in 1.In all the cases no colorectal polyposis was detected . Conclusions HNPCC patients and their family members should be followed up regularly in order to find colorectal cancer at earlier stage.

关 键 词：遗传性 非息肉性 大肠肿瘤 HNPCC 家系分析 

分 类 号：R735.34[医药卫生—肿瘤]