水迷宫评价蛋清高F值寡肽增强小鼠记忆功效的影响因素分析  

Analysis of Influence Factors of Memory Enhancement in Mice Administrated with High F Value Oligopeptide in Water Maze

作　　者：林松毅[1] 许海丽[1] 孟秀娟[1] 高丽霞[1] 孙鹏[1] 刘静波[1] 

机构地区：[1]吉林大学军需科技学院营养与功能食品研究室,吉林长春130062

出　　处：《食品科学》2011年第3期191-194,共4页Food Science

基　　金：国家"863"计划项目(2007AA10Z329)

摘　　要：以蛋清高F值寡肽为受试物,借助SMG-2水迷宫程序自动控制仪4个盲端评价方法,综合分析受试小鼠90d潜伏期变化情况,以考察蛋清高F值寡肽和SMG-2水迷宫4个盲端对小鼠潜伏期的影响。结果表明:给予蛋清高F值寡肽的小鼠在盲端Ⅰ、Ⅱ、Ⅲ区的潜伏期和对照组小鼠的潜伏期都表现出了显著性差异(P<0.05);通过对不同测试时间的潜伏期之间的显著性检验,表明受试小鼠的潜伏期在受试第60天时开始和之前的潜伏期有显著性差异。并且小鼠在盲端Ⅰ、Ⅱ、Ⅲ、Ⅳ区的潜伏期对训练时间的依赖性是逐渐增加的,既迷宫越复杂,小鼠对受试时间的依赖性越弱。SMG-2水迷宫程序自动控制仪评价蛋清高F值寡肽对小鼠的记忆时,选择盲端Ⅰ、Ⅱ区的潜伏期进行统计分析。The objective of this study was to obseive the effect of egg white oligopeptide and the four blind sides on memory enhancing in mice. Based on SMG-2 water maze, the length of incubation period in blind-side I, II, IlI and IV in water maze of mice administered intragastrically with high F value oligopeptide from egg white were measured. The results showed that the mice treated with high F value oligopeptide showed significant differences from the control group. Significance test of differences among latent times after a certain time of administration indicated that latent times in mice after 60 days of administration significantly differed from those after fewer days （30, 40 and 50）. And mice in blind-side I, II, III and IV area had a time- dependent incubation period upon training, implying that the more complex the maze was, the more intense time-dependent was. While evaluating the memory enhancing ability of egg white oligopeptide, it is better to analyze the incubation period of mice in blind-side I and II.

关 键 词：增强记忆 水迷宫 盲端 受试时间 

分 类 号：TS201[轻工技术与工程—食品科学]