藻油及鱼油二十二碳六烯酸复方制剂对儿童记忆功能的影响  

Effects of compound preparations containing docosahexenoic acid from marine algae or from fish oil on memory ability of children

作　　者：丁慧萍[1] 李艳红[1] 丁倩[1] 张福东[1] 王涛[1] 王俐[1] 蔡美琴[1] 

机构地区：[1]上海交通大学医学院营养系,200025

出　　处：《中华临床营养杂志》2011年第2期129-132,共4页Chinese Journal of Clinical Nutrition

摘　　要：目的 研究二十二碳六烯酸（DHA）与大豆磷脂、维生素A复方制剂对儿童记忆功能的影响，并比较藻油和鱼油来源的DHA的作用有无差别。方法选择上海市宝山区某小学年龄在11到12岁之间且知情同意的健康学生160名，采用随机数字表法将受试者分为3组：藻油DHA组（n=53）、鱼油DHA组（n=53）和对照组（n=54）。藻油DHA组服用藻油来源的DHA与大豆磷脂、维生素A复方制剂软胶囊，鱼油DHA组服用鱼油来源的DHA与大豆磷脂、维生素A复方制剂软胶囊，两组的DHA含量相等，均为200mg／粒，其余成分均相同；对照组服用相同外观的软胶囊安慰剂。3组均连续服用30d，每天1粒。试验开始及结束时采用中国科学院心理研究所编制的临床记忆量表评价受试者的记忆能力。结果试验前，3组的各分测验量表分和记忆商差异均无统计学意义（P均〉0．05）。试验后，藻油DHA组和鱼油DHA组与对照组相比除联想学习差异无统计学意义外（P均〉0．05），其他各项量表分及记忆商均明显高于对照组（P均〈0．05）；藻油DHA组和鱼油DHA组间各分测验量表分和记忆商差异均无统计学意义（P均〉0．05）。结论DHA复方制剂对改善儿童记忆力有一定的效果；同等剂量不同来源的DHA对于记忆力的影响无差异。Objective To study the effects of compound preparations which contain doeosahexenoic acid （DHA）, soybean lecithin, and vitamin A on memory ability of children and to compare the difference between two compound preparations that contain DHA from marine algae and from fish oil. Methods Totally 160 11-12-year-old healthy children who were studying in a primary school in Baoshan District of Shanghai were enrolled in this study. All the subjects signed the informed consent form. Subjects were randomly divided into three groups with random numbers ： marine algae DHA group （ n = 53 ）, fish oil DHA group （ n = 53 ）, and control group （ n = 54 ）. Subjects in the marine algae DHA group were given compound preparation which contained DHA form marine algae, soybean lecithin, and vitamin A ; subjects in fish oil DHA group were given compound preparation which contained DHA form fish oil, soybean lecithin, and vitamin A. The dose of DHA （200 mg DHA per capsule） and other components in the two groups was equal. Subjects in the control group were given a placebo with same appearance. The trial lasted 30 days. Each subject took a capsule per day. Immediately before and after the trial, subjects were tested by using the clinical memory scale compiled by the Institute of Clinical Psychology of the Chinese Academy of Sciences. Results Before the trial, there was no difference among three groups in terms of all items of clinical memory scale or memory quotient （all P 〉 0. 05）. After the trial, except for associative learning （ both P 〉 0. 05 ）, the other items of the clinical memory scale and memory quotient in both marine algae DHA group and fish oil DHA group were significantly higher than those of control group （ all P 〈 0. 05 ）. No significant difference was noted between the marine algae DHA group and fish oil DHA group for all items of the clinical memory scale or memory quotient （ all P 〉 0.05 ）. Conclusions DHA compounds can improve the memory ability of children. DHAs with differ

关 键 词：二十二碳六烯酸 儿童 记忆力 

分 类 号：R151.4[医药卫生—营养与食品卫生学]