油茶籽油对大鼠降血脂和预防脂肪肝的影响  

Blood Lipid-lowering and Fatty Liver-preventing Effects of Tea Seed(Camellia oleifera Abel.) Oil in Rats

作　　者：黄翠莉[1] 吴苏喜[1] 刘瑞兴[1] 郝泽金[1] 

机构地区：[1]长沙理工大学化学与生物工程学院,湖南长沙410114

出　　处：《食品科学》2011年第13期332-335,共4页Food Science

基　　金：湖南省科技计划项目(2010WK2004;2010CK3024);湖南省研究生科研创新项目(CX2009B184)

摘　　要：目的:考察油茶籽油辅助降血脂和预防脂肪肝的作用。方法:采用SD大鼠,预饲养4d后随机分成6组(每组10只):A.高脂对照组、B.空白对照组、C.高剂量茶籽油组、D.中剂量茶籽油组、E.低剂量茶籽油组、F.橄榄油对照组;各组每kg体质量的日喂食标准为:A.150g高脂饲料和9.0g生理盐水,B.150g基础饲料和9.0g生理盐水,C.150g高脂饲料和9.0g油茶籽油,D.150g高脂饲料和3.0g油茶籽油,E.150g高脂饲料和1.5g油茶籽油,F.150g高脂饲料和9.0g橄榄油,并以高脂饲料建立高脂模型;连续饲养7周后杀鼠,制备血清以备测定其甘油三酯(TG)、总胆固醇(TC)和高密度脂蛋白胆固醇(HDL-C)含量,并取肝脏进行病理切片、观察其脂肪病变程度。结果:与高脂对照组比较,3个剂量茶籽油组大鼠血清的TG和TC水平均极显著地降低(P<0.01);3个剂量茶籽油组大鼠肝脏的脂肪病变程度明显轻于高脂对照组(P<0.05),其中,高剂量组与橄榄油组类似,即:90%病例为正常肝或轻度脂肪肝,仅10%病例为中度脂肪肝,而且均与空白组的表现接近。结论:油茶籽油具有辅助降血脂作用以及预防脂肪肝的作用。Purpose：To evaluate the effects of tea seed oil on reducing blood lipid and preventing fatty liver in rats.Methods：SD rats were fed for 4 days and then randomly assigned into six groups of 10 rats each：high fat control group（A）,blank control group（B）,high-dose tea seed oil group（C）,medium-dose tea seed oil group（D）,low-dose tea seed oil group（E） and olive oil control group（F）.The daily food intake per kilogram of body weight of group A was 150 g high fat diet ＋ 9.0 g normal saline,of group B 150 g basal diet ＋ 9.0 g normal saline,of group C 150 g high fat diet ＋ 9.0 g tea seed oil,of group D 150 g high fat diet ＋ 3.0 g tea seed oil,of group E 150 g high fat diet ＋ 1.5 g tea seed oil,and of group F 150 g high fat diet ＋ 9.0 g olive oil.High fat models were established by feeding high fat diet.After feeding for 7 consecutive weeks,all rats were killed to determine the levels of serum TG,TC and HDL-C and to observe pathological changes in the liver.Results：Serum TG and TC levels were significantly decreased in tea seed oil-treated rats compared with the high fat control group（P0.01）,and slighter pathological changes were observed in the liver of tea seed oil-treated rats（P0.05）.Moreover,the high-dose tea seed oil group and the olive oil control group had similar pathological changes,with 90% normal or light degree fatty liver and 10% middle degree fatty live,which all exhibited manifestations similar to those of the blank control group.Conclusion：Tea seed oil has blood lipid-lowering and fatty liver-preventing effects.

关 键 词：油茶籽油 大鼠 血脂 脂肪肝 

分 类 号：TS201.4[轻工技术与工程—食品科学]