干细胞移植治疗共济失调七例  

Stem cell transplantation in ataxia:seven cases report

作　　者：侯会荣[1] 李香社[1] 范亚林[1] 

机构地区：[1]石家庄白求恩国际和平医院外宾病房,河北050081

出　　处：《脑与神经疾病杂志》2011年第4期287-290,共4页Journal of Brain and Nervous Diseases

摘　　要：目的探讨异体脐带血干细胞移植治疗共济失调的疗效。方法 7例患者接受了干细胞移植,其中女性4例,男性3例。年龄最大73岁,最小4岁,病史最长17年,最短1年。给予患者异体脐带血干细胞6次移植。移植前后按《世界合作共济失调量表》评分,两次评分进行统计学处理。结果 7例患者的《世界合作共济失调量表》评分均下降,最多下降22分,最少下降9.5分,移植前后的评分比较P=0.0001。结论异体脐带血干细胞移植治疗共济失调短期内观察安全、有效。Objective To study the effective of stem cell transplantation in ataxia patients.There were 7 patients diagnosed as ataxia received stem cell transplantation.Among these 7 cases,aged from 4 years old to 73 years old,4 female and 3 male.The case history ranged from 1 year to 17 years.Method The patients were given umbilical cord blood derived stem cells 6 injections for transplantation.They were evaluated neurologically using ICARS（international cooperation ataxia rating scale） before and after the transplantation then made statistical analysis on the data.Result ICARS score of all patients decreased,ranged from 22 to 9.5.Statistical analysis on the change of their ICARS score showed p=0.0001.Conclusion Umbilical cord blood derived stem cell transplantation is safety and effective for ataxia in short-term observation.Long term result is still in following up.

关 键 词：共济失调 遗传性共济失调 脊髓小脑性共济失调 干细胞移植 脐血干细胞 

分 类 号：R744.7[医药卫生—神经病学与精神病学]