超滤大豆蛋白肽对小鼠免疫功能的影响  

Effect of ultrafiltration soybean peptide on immune function of mice

作　　者：富校轶[1] 李博群[1] 张时莹[1] 姚磊[1] 

机构地区：[1]国家大豆工程技术研究中心东北农业大学,黑龙江哈尔滨150030

出　　处：《食品工业科技》2012年第7期375-378,共4页Science and Technology of Food Industry

基　　金：黑龙江省国际合作课题

摘　　要：目的:研究超滤大豆蛋白肽对小鼠免疫功能的影响。方法:以正常小鼠为实验对象,观察不同剂量(0.85g/kg.bw、1.7g/kg.bw、5.1g/kg.bw)的超滤大豆蛋白肽对小鼠脾脏指数、胸腺指数、小鼠迟发型变态反应(足跖增厚法)、半数溶血值和碳粒廓清指数的影响。结果:与对照组(30.25±2.12)相比,高剂量组和中剂量组的超滤大豆蛋白肽半数溶血值水平[(51.08±8.33),(38.29±5.51)]显著提高[(p<0.01),(p<0.05)];与对照组(4.90±0.63)相比,高剂量组和中剂量组超滤大豆蛋白肽吞噬指数[(5.78±0.69),(5.62±0.57)]显著提高(p<0.05);但各剂量组动物的脾脏指数、胸腺指数以及足趾厚度差无显著性差异(p>0.05)。结论:超滤大豆蛋白肽具有增强免疫功能中体液免疫功能和单核-巨噬细胞吞噬功能的作用。Objective：To study the effect of ultrafiltration soybean peptide on immune-related functions in mice.Methods：The normal mice were chosen as experimental object in order to observe the effect of different doses（0.85g/kg,1.7g/kg,5.1g/kg）of ultrafiltration soybean protein peptide on spleen index,thymus index,late onset allergy（foot palm thickening method）,half hemolysis value and carbon particles clear index in mice.Results：Compared with the control group,the half hemolysis value of high dose and moderate dose of ultrafiltration soybean protein peptide were higher significantly[（51.08±8.33）,（38.29±5.51）][（p0.01）,（p0.05）];the devour index of high dose and moderate dose of ultrafiltration soybean protein peptide were higher significantly[（5.78±0.69）,（5.62±0.57）]（p0.05）.However,there were no significant differences among four groups in the aspect of the spleen index,the thymus index and late onset allergy（foot palm thickening method）（p0.05）.Conclusion：ultrafiltration soybean protein peptide can strengthen humoral immune function and mononuclear-macrophage phagocytosis function.

关 键 词：超滤大豆蛋白肽 免疫调节作用 半数溶血值 迟发型变态反应 

分 类 号：TS201.4[轻工技术与工程—食品科学]