万寿菊提取物缓解视疲劳作用的人体试食试验效果观察  

Clinical observation of effect of marigold extract on asthenopia relief

作　　者：翟鹏贵[1] 赵珺彦[2] 周大兴[1] 郑勇英[3] 

机构地区：[1]浙江中医药大学药学院,浙江杭州310053 [2]杭州市萧山区第一人民医院眼科 [3]上海市疾病预防控制中心

出　　处：《中国预防医学杂志》2012年第4期267-270,共4页Chinese Preventive Medicine

摘　　要：目的研究万寿菊提取物对缓解视疲劳的作用。方法依据《保健食品功能学评价程序和检验方法》(2003年版)中缓解视疲劳的功能评价方法,采用自身对照及组间对照法,选择符合实验条件的志愿受试者120例,随机分为试验组和对照组,每组60人。试验组服用受试物,对照组服用安慰剂,用法与用量同试验组,连续服用45d。试验前后观察视疲劳症状积分、明视视久度、总有效率及远视力等指标。结果试验组的视疲劳症状积分由服用前的2.89±2.77降低至服用后的1.70±1.94(P<0.01);试食后试验组视疲劳症状积分与对照组比较差异有统计学意义(P<0.01);试验组明视持久度提高率为11.21±8.12%,与对照组(0.90±6.39%)比较,差异有统计学意义(P<0.01);试验组总有效率(55.56%)显著高于对照组的(7.84%)(P<0.01);试验组远视力提高幅度比试食前有显著改善(P<0.05)。结论万寿菊提取物能有效缓解人体视疲劳。Objective Effects of marigold extract on asthenopisa relief were studied.Methods Adopting alleviating eye fatigue function assessing methods in Functional Testing and Assessment of Health Food,and using self-control and inter-group control,the 120 volunteers were chosen and randomly divided into experimental group（n=60） and control group（n=60） according to the required conditions.Experimental group received marigold extract everyday for 45 days,while control group only received placebo.Before and in the end of test,score of eye symptom,increased rate of photopic durability,the total efficiency and increased rate of distance vision were observed.Results Score of eye symptom in experimental group decreased significantly during research（P0.01）（from 2.89±2.77 to 1.70±1.94）,and score of eye symptom between experimental group and control group were significantly different（P0.01）;increased rate of photopic durability of experimental group was 11.21±8.12%（P0.01）;and difference of the increased rate of photopic durability between experimental group and control group（0.90±6.39%） was significant（P0.01）;the total efficiency in experimental group（55.56%）were significantly higher than that in control group（7.84%）（P0.01）;increased rate of distance vision of experimental group was significant during research（P0.05）.Conclusions The marigold extract can alleviate asthenopia effectively.

关 键 词：视疲劳 万寿菊提取物 叶黄素 玉米黄素 

分 类 号：R151[医药卫生—营养与食品卫生学] R771[医药卫生—公共卫生与预防医学]