肝素提取纯化技术研究进展  

Research progress in extraction and purification technology of heparin

作　　者：王国栋[1] 杨佳艺[1] 杨佳[1] 李洪军[1,2] 

机构地区：[1]西南大学食品科学学院,重庆400716 [2]重庆市特色食品工程技术研究中心,重庆400716

出　　处：《食品工业科技》2012年第9期436-440,共5页Science and Technology of Food Industry

基　　金：农业部公益性行业科研专项(200903012);国家现代农业(兔)产业技术体系岗位科学家经费

摘　　要：肝素是一类结构异常复杂的糖胺聚糖混合物,因具有多种生物学功能,其提取纯化方法一直是各国学者研究的热点。文章概述了肝素的结构特点及理化性质,对肝素提取纯化技术进行了综述,重点阐述了分离纯化技术的最新研究进展,包括凝胶过滤层析、离子交换层析、亲和层析及毛细血管电泳等,展望了肝素未来的研究趋势。Heparin is a class of very complex structures mixed of glycosaminoglycans.Because of a variety of biological functions,its extraction and purification methods has been a hot research scholars all over the world.The structural characteristics of heparin and the physical and chemical properties were summarized,extraction and purification technology of heparin were reviewed,focusing on separation and purification technology,the latest research,including gel filtration chromatography,ion exchange chromatography,affinity chromatography and capillary electrophoresis and look forward to future research trends of heparin.

关 键 词：肝素 结构 提取 分离纯化 

分 类 号：TS201.1[轻工技术与工程—食品科学]