133例智力低下患儿细胞遗传学研究  

Chromosome analysis in 133 children with congenital mental retardation

作　　者：马宁[1] 杨晓[1] 朱丽娜[1] 王春枝[1] 

机构地区：[1]北京军区总医院附属八一儿童医院临床遗传学中心,100700

出　　处：《中国优生与遗传杂志》2012年第8期62-63,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨智力低下患儿与染色体异常的关系。方法常规外周血染色体核型分析。结果 133例患儿中共检出染色体异常74例,异常检出率55.6%。其中常染色体数目异常62例,结构异常9例;性染色体数目异常2例,结构异常1例,结论染色体异常是导致儿童智力低下的重要原因,对此类患儿进行染色体核型分析很有必要。Objective： To explore the chromosome karyotypes in children with mental retardation. Methods： The peripheral blood lymphocytes from 133 children with congenital mental retardation were cultured and analysed by the G- band technique. Results： Of the 133 cases, 74cases （55.6%） showed chromosome abnormalities. The number of autosomal abnormalities were found in 62 cases arid Autosomal structural chromosome abnormalities were found in 9 cases, the number of sex chromosome abnormalities in 2 cases and sex chromosome structural abnormalities in 1 cases. Conclusions： Chromosome abnormalities may be important cytogenetic factors for congenital mental retardation. Cytogenetic chromosome karyotypic analysis is an important method for congenital mental retardation child.

关 键 词：智力低下 染色体异常 儿童 

分 类 号：R749.94[医药卫生—神经病学与精神病学]