氟苯尼考-β-环糊精包合物的结构表征  

Structure identification of inclusion complex of Florfenicol with β-cyclodextrin

作　　者：赵玲[1] 苏健裕[1] 陈建平[1] 胡松青[1] 李琳[1] 

机构地区：[1]华南理工大学轻工与食品学院,广东广州510640

出　　处：《食品工业科技》2012年第20期148-150,155,共4页Science and Technology of Food Industry

基　　金：广东省自然科学基金博士启动项目(10451064101005160);国家自然科学基金(31101278;31130042);中央高校基本科研业务费专项资金资助(2011ZM0099);国家十二五科技支撑计划项目(2012BAD37B01)

摘　　要：目的:利用超声波法制备氟苯尼考-β-环糊精包合物,并对其结构进行表征。方法:以β-环糊精为包合剂,采用超声法制备氟苯尼考包合物,工艺参数为氟苯尼考与β-环糊精投料比1:1(mol/mol),超声温度60℃,超声时间5h。然后分别采用傅里叶红外光谱法(FIIR)、X-射线粉末衍射法(XRD)对包合物进行结构表征。结果:在该制备工艺条件下包合物的得率为93.52%,包合率为38.09%;且经过FIIR和XRD确证其包合物已形成。结论:采用本实验工艺具有较好的得率,氟苯尼考被β-环糊精包合后呈现出新的物相特征。Objective：To prepare and identify the inclusion complex of florfenicol with β-cyclodextrin. Methods： The inclusion complex was obtained by the ultrasonic method,the preparation conditions were as follows：ratio of Florfenicol and β-cyclodextrin was 1：1 （mol/mol）,ultrasound temperature was 60℃, ultrasound time for 5h, and identified the structure of inclusion complex by the methods of Fourier infrared spectrum（FIIR） and X-ray powder diffractometry（XRD）. Results.The yield of inclusion complex was 93.52% and the inclusion ratio of inclusion complex was 38.09% under these conditions. At the same time, the formation of inclusion complex was proofed by FIIR and XRD. Conclusion： This technology had good yield and the Florfenicol-β-cyclodextrin inclusion complex exhibited some new physical characteristic.

关 键 词：氟苯尼考 Β-环糊精 包合物 结构表征 

分 类 号：TS201.2[轻工技术与工程—食品科学]