葛根黄酮的壳聚糖颗粒的制备及其释放性研究  

Production process of pueraria flavonoids particle and its properties

作　　者：陈周潭[1] 吴晖[1] 赖富饶[1] 李晓凤[1] 

机构地区：[1]华南理工大学轻工与食品学院,广东广州510640

出　　处：《食品工业科技》2012年第23期236-239,共4页Science and Technology of Food Industry

基　　金：国家自然科学基金资助项目(20906031);教育部新世纪优秀人才支持计划资助项目(NECT-06-0746)

摘　　要：以葛根黄酮提取物为芯材,壳聚糖和三聚磷酸钠(TPP)为包裹材料,制备葛根黄酮的壳聚糖颗粒。以包埋率为指标筛选壳聚糖颗粒制备的工艺条件,并通过扫描电子显微镜和X-射线衍射初步分析其性质,同时通过体外药物释放实验评价其释放性能。结果表明:葛根黄酮的壳聚糖颗粒的最佳制备条件为6mg/mL的1mL葛根黄酮溶液,0.6%(m/v)的20mL壳聚糖溶液,0.6%(m/v)的20mLTPP溶液,在此条件下包埋率可达到67.1%。所制备的颗粒的体外释放缓慢且完全,12h时释放率能达到90%,能有效提高葛根黄酮的生物利用率,表明本实验条件下制备的葛根黄酮的壳聚糖颗粒较为成功,达到了预期要求。Pueraria flavonoids particles were prepared by using pueraria flavone as core materials. Particles walls were prepared by chitosan and sodium tripolyphosphate（TPP）.The pueraria flavone were added to the chitosan solution and this was added drop wise to the sodium tripolyphosphate solution while stirring,then freeze drying. Encapsulation efficiency was used as the main evaluating index, decide the optimum composition of particles walls.Its appearance was observed by SEM and XRD, and its release properties were analyzed. The optimum composition of nanoparticles： pueraria fiavone 6mg/mL, chitosan solution 0.6% （m/v）, TPP 0.6% （m/v）. The encapsulation efficiency reached to 67.1%. Pueraria flavonoids nanoparticles in vitro released slowly and completely.The release rate reached to 90% in 12h improving the rate of biological utilization.Pueraria flavonoids particles were prepared successfully by this way as expected.

关 键 词：葛根黄酮 壳聚糖 三聚磷酸钠 释放性 

分 类 号：TS209[轻工技术与工程—食品科学]