Wntless in Wnt secretion： molecular, cellular and genetic aspects  

作　　者：Soumyashree DAS Shiyan YU Ryotaro SAKAMORI Ewa Stypulkowski Nan GAO 

机构地区：[1]Department of Biological Sciences, Rutgers University , Newark, NJ 07102, USA

出　　处：《Frontiers in Biology》2012年第6期587-593,共7页生物学前沿（英文版）

摘　　要：Throughout the animal kingdom, Wnt-triggered signal transduction pathways play fundamental roles in embryonic development and tissue homeostasis. Wnt proteins are modified as glycolipoproteins and are secreted into the extracellular environment as morphogens. Recent studies on the intraceHular trafficking of Wnt proteins demonstrate multiple layers of regulation along its secretory pathway. These findings have propelled a great deal of interest among researchers to further investigate the molecular mechanisms that control the release of Wnts and hence the level of Wnt signaling. This review is dedicated to Wntless, a putative G-protein coupled receptor that transports Wnts intracellularly for secretion. Here, we highlight the conclusions drawn from the most recent cellular, molecular and genetic studies that affirm the role of Wntless in the secretion of Wnt proteins.Throughout the animal kingdom, Wnt-triggered signal transduction pathways play fundamental roles in embryonic development and tissue homeostasis. Wnt proteins are modified as glycolipoproteins and are secreted into the extracellular environment as morphogens. Recent studies on the intraceHular trafficking of Wnt proteins demonstrate multiple layers of regulation along its secretory pathway. These findings have propelled a great deal of interest among researchers to further investigate the molecular mechanisms that control the release of Wnts and hence the level of Wnt signaling. This review is dedicated to Wntless, a putative G-protein coupled receptor that transports Wnts intracellularly for secretion. Here, we highlight the conclusions drawn from the most recent cellular, molecular and genetic studies that affirm the role of Wntless in the secretion of Wnt proteins.

关 键 词：Wntless Gpr177 WNT TRAFFICKING SECRETION EXOCYTOSIS RETROMER 

分 类 号：Q26[生物学—细胞生物学] S852.23[农业科学—基础兽医学]