Advance in herpes simplex viruses for cancer therapy  

作　　者：LIU ShangLong DAI MeiHua YOU Lei ZHAO YuPei 

机构地区：[1]Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College

出　　处：《Science China(Life Sciences)》2013年第4期298-305,共8页中国科学（生命科学英文版）

基　　金：supported by the National Natural Science Foundation of China (81071898)

摘　　要：Oncolytic virotherapy is an attractive approach that uses live viruses to selectively kill cancer cells. Oncolytic viruses can be genetically engineered to induce cell lyses through virus replication and cytotoxic protein expression. Herpes simplex virus (HSV) has become one of the most widely clinically used oncolytic agent. Various types of HSV have been studied in basic or clinical research. Combining oncolytic virotherapy with chemotherapy or radiotherapy generally produces synergic action with unclear molecular mechanisms. Arming HSV with therapeutic transgenes is a promising strategy and can be used to complement conventional therapies. As an efficient gene delivery system, HSV has been successfully used to deliver various immuno-modulatory molecules. Arming HSV with therapeutic genes merits further investigation for potential clinical application.Oncolytic virotherapy is an attractive approach that uses live viruses to selectively kill cancer cells. Oncolytic viruses can be genetically engineered to induce cell lyses through virus replication and cytotoxic protein expression. Herpes simplex virus （HSV） has become one of the most widely clinically used oncolytic agent. Various types of HSV have been studied in basic or clinical research. Combining oncolytic virotherapy with chemotherapy or radiotherapy generally produces synergic action with unclear molecular mechanisms. Arming HSV with therapeutic transgenes is a promising strategy and can be used to comple- ment conventional therapies. As an efficient gene delivery system, HSV has been successfully used to deliver various immuno- modulatory molecules. Arming HSV with therapeutic genes merits further investigation for potential clinical application.

关 键 词：oncolytic viruses HERPESVIRUS VIROTHERAPY CANCER gene therapy 

分 类 号：R730.5[医药卫生—肿瘤]