Oncolytic viral immunotherapy is gaining considerable prominence in the realm of chronic diseases treatment and rehabilitation.Oncolytic viral therapy is an intriguing therapeutic approach due to its low toxicity and ...
Supported by the Public Welfare Technology Project of Zhejiang Province,No.LGF21H160033;Zhejiang Medical Technology Plan Project,No.2021KY047;Hangzhou Medical Health Science and Technology Project,No.B20220173.
Hepatocellular carcinoma(HCC)is a systemic disease with augmented malignant degree,high mortality and poor prognosis.Since the establishment of the immune mechanism of tumor therapy,people have realized that immunothe...
Breast cancer,an unceasingly occurring neoplasm,is one of the major determinants of mortality in women.Several ineffective attempts have been pursued using with conventional therapies against breast cancer.Resistance ...
This work was partly supported by NCI grant R01CA229818 to Garcia-Sastre A.
Oncolytic viruses(OVs)are at the forefront of biologicals for cancer treatment.They represent a diverse landscape of naturally occurring viral strains and genetically modified viruses that,either as single agents or a...
Cancer is a common term for many diseases that can affect any part of the body.In 2020,ten million people will die due to cancer.A worldwide leading cause of death is cancer by the World Health Organization(WHO)report...
Immunotherapy, while effective against lymphoid cancers and some solid tumors, has shown less benefit against pediatric brain tumors. Tumor heterogeneity, a suppressive immune microenvironment, and the blood-brain bar...
Among oncolytic viruses, the vesicular stomatitis virus(VSV) is especially potent and a highly promising agent for the treatment of cancer. But, even though effective against multiple tumor entities in preclinical ani...
In humans colorectal cancer (CRC) is a significant cause of morbidity and mortality. New treatment options are urgently needed to supplement existing therapies. Replication-competent oncolytic viruses (RCOVs) for the ...
supported by the National Natural Science Foundation of China (81071898)
Oncolytic virotherapy is an attractive approach that uses live viruses to selectively kill cancer cells. Oncolytic viruses can be genetically engineered to induce cell lyses through virus replication and cytotoxic pro...