ONCOLYTIC

作品数：39被引量：93H指数：6
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相关领域：医药卫生生物学更多>>
相关作者：张文刘尚梅刘滨磊李洁董英更多>>
相关机构：中国医学科学院肿瘤医院首都医科大学更多>>
相关期刊：《Cellular & Molecular Immunology》《Acta Pharmacologica Sinica》《Virologica Sinica》《World Journal of Gastroenterology》更多>>
相关基金：国家自然科学基金广东省自然科学基金俄罗斯基础研究基金中国博士后科学基金更多>>
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Immunotherapy for glioblastoma:current state,challenges,and future perspectives
《Cellular & Molecular Immunology》2024年第12期1354-1375,共22页Yang Liu Fei Zhou Heba Ali Justin D.Lathia Peiwen Chen 
supported in part by National Institutes of Health(NIH)R01 NS127824(PC),NIH R01 NS124594(PC),NIH P01 CA245705(JDL),R35 NS127083(JDL);the Department of Defense(DoD)Career Development Award W81XWH-21-1-0380(P.C.),as well as the Lerner Research Institute and Case Comprehensive Cancer Center.
Glioblastoma(GBM)is an aggressive and lethal type of brain tumor in human adults.The standard of care offers minimal clinical benefit,and most GBM patients experience tumor recurrence after treatment.In recent years,s...
关键词：GLIOBLASTOMA Immune checkpoint inhibitors(ICIs) Adoptive T-cell therapies Tumor vaccines Oncolytic viral therapies Immunotherapy combination 
A novel vesicular stomatitis virus armed with IL-2 mimic for oncolytic therapy
《Virologica Sinica》2024年第5期821-832,共12页Manman Wu Yiwei Wang Chuanjian Wu Huang Huang Xinyuan Zhou Jun Wang Sidong Xiong Chunsheng Dong 
Oncolytic virus(OV)is increasingly being recognized as a novel vector in cancer immunotherapy.Increasing evidence suggests that OV has the ability to change the immune status of tumor microenvironment,so called transf...
关键词：Combination therapy IL-2 mimic Neo-2/15 Oncolytic virus(OV) Tumor immunity Vesicular Stomatitis virus(VSV) 
Insights into therapeutic peptides in the cancerimmunity cycle:Update and challenges
《Acta Pharmaceutica Sinica B》2024年第9期3818-3833,共16页Xiaokun Zhang Ye Wu Jiayi Lin Shengxin Lu Xinchen Lu Aoyu Cheng Hongzhuan Chen Weidong Zhang Xin Luan 
the National Natural Science Foundation of China(Nos.82322073,82173846,and 82304533);CAMS Innovation Fund for Medical Sciences(CIFMS)(No.2023-I2M-3-009,China);Oriental Scholars of Shanghai Universities(TP2022081,China);China Postdoctoral Science Foundation(No.2021M702215);Jiangxi Province Thousand Talents Program(jxsq2023102168,China);Young Talent Lifting Project of Young Talent Lifting Project of China Association of Chinese Medicine[No.CACM-(2021-QNRC2-A08)];Shanghai Rising-Star Program(No.22QA1409100,China);Shanghai Sailing Program(No.22YF1445000,China);2021 Shanghai Science and Technology Innovation Action Plan(No.21S11902800,China);Three-Year Action Plan for Three-year Action Plan for Shanghai TCM Development and Inheritance Program[No.ZY(2021-2023)-0208 and ZY(2021-2023)-0401,China];High level Key Discipline of National Administration of Traditional Chinese Medicine(No.zyyzdxk-2023071,China);Innovation Team and Talents Cultivation Program of High level Key Discipline of National Administration of Traditional Chinese Medicine(No.ZYYCXTD-D-202004,China);Key project at central government level:The ability establishment of sustainable use for valuable Chinese medicine resources(No.2060302,China);Innovation team of high-level local universities in Shanghai:Strategic Innovation Team of TCM Chemical Biology(China).All figures were created with BioRender.com.
Immunotherapies hold immense potential for achieving durable potency and long-term survival opportunities in cancer therapy.As vital biological mediators,peptides with high tissue penetration and superior selectivity ...
关键词：Cancer-immunity cycle Oncolytic peptide Peptide neoantigen vaccine Peptide mimotope Immune checkpoint blockade Cancer immunotherapy Synthetic long peptide vaccine Peptide-major histocompatibility complex 
From oncolytic peptides to oncolytic polymers:A new paradigm for oncotherapy
《Bioactive Materials》2024年第1期206-230,共25页Hanmeng Liu Wei Shen Wanguo Liu Zexin Yang Dengke Yin Chunsheng Xiao 
financially supported by National Natural Science Foundation of China[52203154 and 52222307];the Key Project of Anhui Provincial Department of Education[KJ2021A0543];Anhui University of Chinese Medicine Foundation[2022rcZD003 and 2022rczd010];the Major Fund Project of Anhui Provincial Department of Education[2022AH040077].
Traditional cancer therapy methods,especially those directed against specific intracellular targets or signaling pathways,are not powerful enough to overcome tumor heterogeneity and therapeutic resistance.Oncolytic pe...
关键词：Oncolytic polymers Oncolytic peptides Cancer therapy Therapeutic resistance IMMUNOTHERAPY 
Preclinical and clinical trials of oncolytic vaccinia virus in cancer immunotherapy:a comprehensive review被引量：2
《Cancer Biology & Medicine》2023年第9期646-661,共16页Mengyuan Li Minghuan Zhang Qian Ye Yunhua Liu Wenbin Qian 
supported by the National Natural Science Foundation of China(Grant No.81830006);the Science Technology Department of Zhejiang Province(Grant No.2021C03117).
Oncolytic virotherapy has emerged as a promising treatment for human cancers owing to an ability to elicit curative effects via systemic administration.Tumor cells often create an unfavorable immunosuppressive microen...
关键词：Oncolytic virotherapy oncolytic vaccinia virus engineered virus arming strategy 
Current and emerging therapeutic approaches for colorectal cancer:A comprehensive review被引量：6
《World Journal of Gastrointestinal Surgery》2023年第4期495-519,共25页Anil Kumar Vipasha Gautam Arushi Sandhu Kajal Rawat Antika Sharma Lekha Saha 
Colorectal cancer(CRC)affects 1 in 23 males and 1 in 25 females,making it the third most common cancer.With roughly 608000 deaths worldwide,CRC accounts for 8%of all cancer-related deaths,making it the second most com...
关键词：Colorectal cancer CHEMOTHERAPY IMMUNOTHERAPY RNA interference PROBIOTICS Oncolytic viral therapy 
The hybrid oncolytic peptide NTP-385 potently inhibits adherent cancer cells by targeting the nucleus
《Acta Pharmacologica Sinica》2023年第1期201-210,共10页Hao Yin Xi-tong Chen Qiao-na Chi Yan-nan Ma Xing-yan Fu Shan-shan Du Yun-kun Qi Ke-wei Wang 
This project was supported by grants from the National Natural Science Foundation of China (81973299,22177058,82003647);the China Postdoctoral Science Foundation (2020T130332,2019M652307);the Qingdao postdoctoral application research project.
The use of oncolytic peptides with activity against a wide range of cancer entities as a new and promising cancer therapeutic strategy has drawn increasing attention.The oncolytic peptide LTX-315 derived from bovine l...
关键词：oncolytic peptides LTX-315 rhodamine B hybridization strategy MELANOMA ROS DNA double-strand break intrinsic apoptosis nucleus-targetingpeptides 
Therapeutic Use of Viruses:Newcastle Disease Virus HK84 Oncolytic Treatment for Hepatocellular Carcinoma被引量：1
《Journal of Clinical and Translational Hepatology》2022年第5期783-785,共3页Leonardo Baiocchi Heather Francis Gianfranco Alpini 
supported by the Hickam Endowed Chair,Gastroenterology,Medicine,Indiana University,the Indiana University Health to Dr Alpini,and the Indiana University School of Medicine Strategic Research Initiative to Drs Alpini and Francis and the Senior Career Scientist Award(IK6 BX004601)to Dr Alpini;the Career Scientist Award(IK6BX005226)to Dr Francis.
Hepatocellular carcinoma(HCC)is the most frequent primary liver tumor worldwide and,despite regional therapeutic and diagnostic differences,it stands among the three most lethal cancers found in humans.Resection or ab...
关键词：CARCINOMA HEALING DIAGNOSIS 
Endoscopic ultrasound-guided injectable therapy for pancreatic cancer:A systematic review
《World Journal of Gastroenterology》2022年第21期2383-2395,共13页Jyotroop Kaur Veeravich Jaruvongvanich Vinay Chandrasekhara 
BACKGROUND Given the low survival rate in pancreatic cancer,new therapeutic techniques have been explored,especially for unresectable or borderline resectable disease.Endoscopic ultrasound(EUS)provides real-time imagi...
关键词：Pancreatic ductal adenocarcinoma Endoscopic ultrasound-guided fine-needle injection Local injectable therapy Immunotherapy Chemotherapy Oncolytic viral therapy 
Oncolytic Activity of Wild-type Newcastle Disease Virus HK84 Against Hepatocellular Carcinoma Associated with Activation of Type I Interferon Signaling被引量：4
《Journal of Clinical and Translational Hepatology》2022年第2期284-296,共13页Liming Chen Yongdong Niu Jiating Sun Hong Lin Guoxi Liang Min Xiao Dongmei Shi Jia Wang Huachen Zhu Yi Guan 
supported by research grants from the Guangdong Science and Technology Innovation Strategy Special Found(2019B121205009);the Guangdong Science and Technology Special Found(190830095586328 and 200109155890863)and the Li Ka Shing Foundation.
Background and Aims:Hepatocellular carcinoma(HCC)is listed as one of the most common causes of cancer-related death.Oncolytic therapy has become a promising treatment because of novel immunotherapies and gene editing ...
关键词：Newcastle disease virus Oncolytic effectiveness Type I interferon Hepatocellular carcinoma BIOSAFETY 
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