Oncolytic viruses:A novel treatment strategy for breast cancer  

作　　者：Mohammad Javanbakht Sanaz Tahmasebzadeh Luca Cegolon Nasrin Gholami Mandana Kashaki Hassan Nikoueinejad Mohamad Mozafari Mahsa Mozaffari Shi Zhao Mostafa Khafaei Morteza Izadi Saeid Fathi Reza Akhavan-Sigari 

机构地区：[1]Nephrology and Urology Research Center,Baqiyatallah University of Medical Sciences,Tehran 1435916471,Iran [2]Mehrestan Health Network,Iranshahr University of Medical Sciences,Iranshahr 9966118984,Iran [3]University of Trieste,Department of Medical,Surgical & Health Sciences,Trieste 34128,Italy [4]University Health Agency Giuliano-Isontina (ASUGI),Public Health Department,Trieste,Italy [5]Hematology and Oncology Research Center,Tabriz University of Medical Sciences,Tabriz 5167956561,Iran [6]Shahid Akbarabadi Clinical Research Development Unit (ShACRDU),Iran University of Medical Sciences (IUMS),Tehran 1997673144,Iran [7]Department of General Surgery,Urmia University of Medical Science,Urmia 57147,Iran [8]Department of Pediatrics,Iran University of Medical Sciences,Tehran 1449614535,Iran [9]JC School of Public Health and Primary Care,Chinese University of Hong Kong,Hong Kong Special Administrative Region 999077,China [10]Human Genetics Research Center,Baqiyatallah University of Medical Sciences,Tehran 169875931,Iran [11]Health Research Center,Baqiyatallah University of Medical Sciences,Tehran 1435916471,Iran [12]Razi Vaccine and Serum Research Institute,Agriculture Research,Education and Extension Organization (AREEO),Karaj 11365-1558,Iran [13]Department of Neurosurgery,University Medical Center,Tuebingen 72076,Germany

出　　处：《Genes & Diseases》2023年第2期430-446,共17页基因与疾病（英文）

摘　　要：Breast cancer,an unceasingly occurring neoplasm,is one of the major determinants of mortality in women.Several ineffective attempts have been pursued using with conventional therapies against breast cancer.Resistance to existing therapies and their respective debilitating adverse effects have led research toward a new era of cancer treatment using viruses.Virotherapy constitutes a developing treatment modality with multiple mechanisms of therapeutic activity in which the viruses can be directly oncolyticand can express transgenes or induce host immune response against tumor cells.Several different DNA-and RNA-containing viruses have been considered for virotherapy of breast cancer including adenovirus,herpes virus,vaccinia,reovirus,Newcastle Disease virus,measles virus and vesicular stomatitis virus.This review aims to summarize the viro-therapeutical agents against breast malignancies.Key Scientific Concepts of Review:In this review paper,we proposed a new strategy to virus's combinatorial treatments using several kinds of transgenes and drugs.These recombinant viruses have provided evidence of treatment efficacy against human breast cancer.

关 键 词：ADENOVIRUS Breast cancer Herpes virus Measles virus Newcastle disease virus REOVIRUS VACCINIA Vesicular stomatitis virus VIROTHERAPY 

分 类 号：R730.5[医药卫生—肿瘤]