ADOPTIVE

作品数：61被引量：365H指数：10
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相关领域：医药卫生更多>>
相关作者：魏续仓赵文理李梅生杨娣娣王彤更多>>
相关机构：陕西省人民医院南京军区南京总医院上海交通大学更多>>
相关期刊：《Cellular & Molecular Immunology》《Journal of Cosmetics, Dermatological Sciences and Applications》《World Journal of Gastroenterology》《Journal of Clinical and Translational Hepatology》更多>>
相关基金：国家自然科学基金高等学校学科创新引智计划国家重点基础研究发展计划更多>>
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Immunotherapy for glioblastoma:current state,challenges,and future perspectives
《Cellular & Molecular Immunology》2024年第12期1354-1375,共22页Yang Liu Fei Zhou Heba Ali Justin D.Lathia Peiwen Chen 
supported in part by National Institutes of Health(NIH)R01 NS127824(PC),NIH R01 NS124594(PC),NIH P01 CA245705(JDL),R35 NS127083(JDL);the Department of Defense(DoD)Career Development Award W81XWH-21-1-0380(P.C.),as well as the Lerner Research Institute and Case Comprehensive Cancer Center.
Glioblastoma(GBM)is an aggressive and lethal type of brain tumor in human adults.The standard of care offers minimal clinical benefit,and most GBM patients experience tumor recurrence after treatment.In recent years,s...
关键词：GLIOBLASTOMA Immune checkpoint inhibitors(ICIs) Adoptive T-cell therapies Tumor vaccines Oncolytic viral therapies Immunotherapy combination 
Advancements in adoptive CAR immune cell immunotherapy synergistically combined with multimodal approaches for tumor treatment
《Bioactive Materials》2024年第12期379-403,共25页Yun Chang Mingyang Chang Xiaoping Bao Cheng Dong 
supported by start-up package funding from The Hong Kong Polytechnic University(Y.C.).
Adoptive immunotherapy,notably involving chimeric antigen receptor(CAR)-T cells,has obtained Food and Drug Administration(FDA)approval as a treatment for various hematological malignancies,demonstrating promising prec...
关键词：Adoptive cellular immunotherapy Immune cell engineering Multiple-model synergistic therapy Tumor microenvironment 
Remolding the tumor microenvironment by bacteria augments adoptive T cell therapy in advanced-stage solid tumors
《Signal Transduction and Targeted Therapy》2024年第12期5765-5776,共12页Chaojie Zhu Chao Liu Qing Wu Tao Sheng Ruyi Zhou En Ren Ruizhe Zhang Zhengjie Zhao Jiaqi Shi Xinyuan Shen Zhongquan Sun Zhengwei Mao Kaixin He Lingxiao Zhang Yuan Ding Zhen Gu Weilin Wang Hongjun Li 
supported by the National Key R&D Program of China(2021YFA0909900);the National Natural Science Foundation of China(52173142,52233013);the“Pioneer”and“Leading Goose”R&D Program of Zhejiang(2024C03168);the Startup Package of Zhejiang University.
The intricate tumor microenvironment presents formidable obstacles to the efficacy of adoptive T cell therapy in the management of solid tumors by limiting the infiltration and inducing exhaustion of the transferred T...
关键词：ADOPTIVE TRANSFERRED solid 
Redefining the tumor microenvironment with emerging therapeutic strategies
《Oncology Research》2024年第11期1701-1708,共8页SULING XU XIAO LI WENXUE MA 
supported by a grant from the Public Welfare Projects of Ningbo,China(2020S065);the Health Major Science and Technology Planning Project of Zhejiang,China(WKJ-ZJ-2411),and a grant from the Project of Ningbo Leading Medical&Health Discipline(2022-F23).
The environment surrounding a tumor,known as the tumor microenvironment(TME),plays a role in how cancer progresses and responds to treatment.It poses both challenges and opportunities for improving cancer therapy.Rece...
关键词：Tumor microenvironment(TME) Cancer immunotherapy Cytokine targeting Extracellular vesicles(EVs) Adoptive cell transfer(ACT) 
Immunotherapy for hepatocellular carcinoma
《Chinese Medical Journal》2024年第15期1765-1776,共12页Xiaoxia Wang Jun Lu 
supported by grants from the National Key R&D Program of China(No.2022YFA0912400);the Original Exploration Program of the National Natural Science Foundation of China(No.82150110);the Beijing Hospitals Authority’s Ascent Plan(Code:DFL20221502).
Hepatocellular carcinoma(HCC)is a leading cause of cancer-related deaths worldwide.Its high recurrence rate and lack of effective control drugs result in a 5-year survival rate of only about 10%.HCC is a tumor regulat...
关键词：IMMUNOTHERAPY Immune checkpoint inhibitors Adoptive cell therapies Hepatocellular carcinoma 
Advancing cell-based therapy in sepsis:An anesthesia outlook
《Chinese Medical Journal》2024年第13期1522-1534,共13页Hui Ye Xiaoyu Zou Xiangming Fang 
National Natural Science Foundation of China(No.82230074)
Sepsis poses a health challenge globally owing to markedly high rates of morbidity and mortality.Despite employing bundle therapy over two decades,approaches including transient organ supportive therapy and clinical t...
关键词：SEPSIS PERIOPERATIVE Receptors chimeric antigen Immunotherapy adoptive Perfusion Tissue repair Multiple organ failure Shock septic 
XELOX(capecitabine plus oxaliplatin)plus bevacizumab(anti-VEGF-A antibody)with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal cancer:a multicenter,open-label,randomized,controlled,phase 3 trial被引量：1
《Signal Transduction and Targeted Therapy》2024年第5期2104-2113,共10页Qiu-Zhong Pan Jing-Jing Zhao Liang Liu Dong-Sheng Zhang Li-Ping Wang Wen-Wei Hu De-Sheng Weng Xiang Xu Yi-Zhuo Li Yan Tang Wei-Hong Zhang Jie-Yao Li Xiao Zheng Qi-Jing Wang Yong-Qiang Li Tong Xiang Li Zhou Shuang-Ning Yang Chen Wu Rong-Xing Huang Jia He Wei-Jiao Du Lu-Jun Chen Yue-Na Wu Bin Xu Qiong Shen Yi Zhang Jing-Ting Jiang Xiu-Bao Ren Jian-Chuan Xia 
This study was funded by the National Key R&D Program of China for J‐CX(grant number 2018YFC1313400);the National Natural Science Foundation of China for J.‐C.X.(grant number 81773110).We express our gratitude to all participating patients and their families,as well as to the study groups and investigators from the participating centers.
Fluoropyrimidine-based combination chemotherapy plus targeted therapy is the standard initial treatment for unresectable metastatic colorectal cancer(mCRC),but the prognosis remains poor.This phase 3 trial(ClinicalTri...
关键词：PD1 immunotherapy BEVACIZUMAB 
Recent advances and remaining challenges in lung cancer therapy
《Chinese Medical Journal》2024年第5期533-546,共14页Tasha Barr Shoubao Ma Zhixin Li Jianhua Yu 
Lung cancer remains the most common cause of cancer death.Given the continued research into new drugs and combination therapies,outcomes in lung cancer have been improved,and clinical benefits have been expanded to a ...
关键词：Lung cancer THERAPY IMMUNOTHERAPY Combination therapy Adoptive T cell therapies 
Expanded clinical-grade NK cells exhibit stronger effects than primary NK cells against HCMV infection被引量：7
《Cellular & Molecular Immunology》2023年第8期895-907,共13页Qian-Nan Shang Xing-Xing Yu Zheng-Li Xu Yu-Hong Chen Ting-Ting Han Yuan-Yuan Zhang Meng Lv Yu-Qian Sun Yu Wang Lan-Ping Xu Xiao-Hui Zhang Xiang-Yu Zhao Xiao-Jun Huang 
supported by the National Key Research and Development Program of China (grant 2022YFA1103300);Major of the National Natural Science Foundation of China (No.82293630);Key Program of the National Natural Science Foundation of China (No. 81930004);National Natural Science Foundation of China (grants 81870140, 82070184, 82270228 and 81370666);It was further supported through the Peking University People’s Hospital Research and Development Funds (grant RDX2019-14, RDL2021-01).
Cytomegalovirus (CMV) reactivation remains a common complication and leads to high mortality in patients who undergo allogeneic hematopoietic stem cell transplantation (allo-HSCT). Early natural killer (NK) cell recon...
关键词：Allogeneic haematopoietic stem cell transplantation Natural killer cells Human cytomegalovirus infection Adoptive infusion 
Neuro faces of beneficial T cells:essential in brain,impaired in aging and neurological diseases,and activated functionally by neurotransmitters and neuropeptides被引量：7
《Neural Regeneration Research》2023年第6期1165-1178,共14页Mia Levite 
T cells are essential for a healthy life,performing continuously:immune surveillance,recognition,protection,activation,suppression,assistance,eradication,secretion,adhesion,migration,homing,communications,and addition...
关键词：AGING dopamine GLUTAMATE nerve-driven immunity neurological diseases NEUROPEPTIDES NEUROTRANSMITTERS Personalized Adoptive Neuro-Immunotherapy T cells 
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