荞麦芽提取物抗突变和抑制肿瘤作用的实验研究  

Study on antimutangenic andantitumor effect of buckwheat sprout extracts

作　　者：孙国娟[1] 李善姬[2] 崔泰花[3] 崔承弼[3] 

机构地区：[1]延边大学医学院,吉林延吉133002 [2]吉林医药学院公共卫生院,吉林132013 [3]延边大学农学院,吉林延吉133002

出　　处：《食品工业科技》2013年第11期343-345,349,共4页Science and Technology of Food Industry

基　　金：国家自然科学基金项目(30960239)

摘　　要：对荞麦芽提取物的抗突变和抗肿瘤作用进行研究,为开发荞麦的保健作用提供依据。实验以小鼠骨髓细胞微核实验观察荞麦芽提取物的抗突变作用,以小鼠S-180移植性肿瘤观察荞麦芽提取物的抗肿瘤效果。结果显示,荞麦芽提取物对N-甲基-N-硝基-N-亚硝基胍(MNNG)诱发的小鼠骨髓细胞微核的发生有明显的抑制效果,其中荞麦芽乙醇提取物、乙酸乙酯提取物、正丁醇提取物在80mg/kg度下,对小鼠骨髓微核的抑制率达73.4%、75.8%、74.2%;对小鼠S-180移植性肿瘤生长也有明显的抑制作用,其中荞麦芽乙醇提取物、乙酸乙酯提取物的抑瘤率达39.5%、38.0%。说明荞麦芽对体细胞DNA损伤有保护作用,对肿瘤也有一定的预防作用。The antimutangenic and antitumor effect of buckwheat sprout extracts were studied to provide scientific basis for exploiting health function of buckwheat sprout.Antimutangenic effect of buckwheat sprout extracts were testified based on the mice bone marrow cell micronuclei test.Antitumor effects of buckwheat sprout extracts were testified based on S-180 tumor cell transplanting test.The micronuclei frequency induced by MNNG in mouse bone marrow cells was inhibited significantly by buckwheat sprout extracts.Under 80mg/kg, buckwheat ethanol extract, ethyl acetate extract and butanol extract on mouse bone marrow micronucleus inhibition rate reached to 73.4%, ？5.8% ,74.2%.Buckwheat sprout extracts on the growth of transplanted tumor of mouse S-180 also had the obvious inhibitory action, including buckwheat sprout ethanol extract, ethyl acetate extract tumor inhibition rate reached to 39.5% ,38.0%.Buckwheat sprouts had preventive effect on DNA damage in body cell,and had inhibitory effect on tumor growth.

关 键 词：荞麦芽 抗突变 微核 抗肿瘤 S-180 

分 类 号：TS201.4[轻工技术与工程—食品科学]