鳕鱼皮胶原蛋白肽的促钙吸收作用  

Calcium absorption increasing effect of collagen peptide from skin of Walleye Pollock

作　　者：卢玉坤[1] 姜慧明[1] 王景峰[1] 王珊珊[1] 杨霞[1] 李八方[1] 

机构地区：[1]中国海洋大学食品科学与工程学院,山东青岛266003

出　　处：《中国海洋药物》2013年第4期49-56,共8页Chinese Journal of Marine Drugs

基　　金：国家海洋公益性行业科研专项(201105029;201205027);中国博士后科学基金(2012M511549)资助;中央高校青年教师科研专项基金项目(201313002)资助

摘　　要：目的探究鳕鱼皮胶原蛋白酶解制得梯级多肽的促钙吸收作用。方法从鳕鱼皮中提取胶原蛋白并酶解制得不同分子量段的胶原多肽,采用低钙饮食建造大鼠缺钙模型,检测大鼠骨钙含量、钙代谢指标和血清钙磷指标,探讨其促钙吸收作用。结果与加钙组相比,各受试物均能提高大鼠骨钙含量;高低剂量的高分子量胶原多肽能显著提高钙吸收率(P<0.05),高低剂量的低中分子量胶原多肽能极显著提高钙吸收率(P<0.01);而高低剂量的中分子量胶原多肽还能显著提高钙储留率(P<0.05),高低剂量的低分子量胶原多肽能极显著提高钙储留率(P<0.01);同时,各受试物也能相应的提高大鼠的血清钙磷含量。结论鳕鱼皮胶原蛋白多肽能明显提高大鼠对钙的吸收率和储留率,分子量越小,其促钙吸收效果越好。Objective To investigate the calcium absorption increasing effect of collagen enzymatic cascade polypeptide from skin of Walleye Pollock. Methods The collagen was extracted from skin of Walleye Pollock and then broken down by enzymes into collagen peptide. The rat calcium deficiency model in- duced by low calcium diet was used to investigate the calcium absorption increasing effect by detecting the bone calcium content, the calcium metabolism indicators and the serum calcium and phosphorus in- dicators. Results Compared with calcium-fortified group, all the test substance samples increased the bone calcium content. The high and low doses of high molecular weight collagen peptide significantly increased the calcium absorption rate （P^0.05） ;the high and low doses of medium molecular weight collagen peptide and low molecular weight collagen peptide more significantly increased the calcium ab sorption rate （P^0. 01）. The high and low doses of medium molecular weight collagen peptide also sig nificantly increased the calcium retention rate （P〈0. 05）; the high and low doses of low molecular weight collagen peptide more significantly increased the calcium retention rate （P〈0. 01）. At the same time, the test substance samples also increased the serum calcium and phosphorus content accordingly. Conclusions collagen peptide from skin of Walleye Pollock can significantly increase the calcium absorp-tion rate and calcium retention rate and the smaller molecular weight, the better the effect of promoting calcium absorption.

关 键 词：鳕鱼皮 胶原蛋白肽 钙代谢 促钙吸收 骨钙 血钙 

分 类 号：R965[医药卫生—药理学]