L-核糖的生产研究进展  

Research progress in production of L-ribose

作　　者：詹伊婧[1] 徐铮[1] 许露[1] 李莎[1] 徐虹[1] 

机构地区：[1]南京工业大学食品与轻工学院材料化学工程国家重点实验室,南京211800

出　　处：《生物加工过程》2013年第5期74-78,共5页Chinese Journal of Bioprocess Engineering

基　　金：国家高技术研究发展计划(863计划)(2012AA021503);高等学校博士学科点专项科研基金(博士生导师类)(20103221110006)

摘　　要：L-核糖是合成许多抗病毒药物的关键中间体,自然界和生物体中并不存在。L-核糖的制备方法有化学合成法和生物合成法。与化学合成法相比,生物合成法对环境更加有利。生物合成法是应用微生物及其酶以核糖醇或L-阿拉伯糖为原料生产L-核糖。综述了L-核糖的制备方法以及产品的分离纯化技术,并对L-核糖的研究现状和前景进行了展望。L-ribose is a non-natural and expensive sugar that can be used as an important intermediate for the synthesis of L-nucleoside analogues. Compared with chemical production, biotechnological methods can produce L-ribose from biomass under environmentally friendly conditions. Various strategies for synthesizing L-ribose by applying microorganisms and their enzymes are discussed, including producing L-ribose from ribitol and L-arabinose. Furthermore, subsequent isolation-and-purification techniques, as an integral step in the whole process, are described, containing the especial introduction of a promising strategy of L-ribose separation. Particularly, further researches and outlook for the improvement of L-ribose preparation are solely stressed. Compared with each method, the mini-review will launch a discussion on the production of L-ribose and its prospect.

关 键 词：L-核糖 生物催化 核糖醇 L-阿拉伯糖异构酶 甘露糖-6-磷酸异构酶 

分 类 号：TQ464[化学工程—制药化工]