鼠曲草总黄酮对糖尿病小鼠血脂代谢紊乱改善作用的研究  

Study on effect of the total flavonoids from Gnaphlium affine D.C. on metabolism of glucose and lipids in diabetic mice

作　　者：崔珏[1] 李超[1] 苏颖[1] 周丽[1] 

机构地区：[1]徐州工程学院食品(生物)工程学院,江苏省食品资源开发与质量安全重点建设实验室,江苏徐州221000

出　　处：《食品工业科技》2013年第22期324-327,共4页Science and Technology of Food Industry

基　　金：江苏省高校自然科学基金(12KJB550002)

摘　　要：鼠曲草总黄酮对糖尿病小鼠糖脂代谢紊乱的改善作用。首先采用腹腔注射链脲佐菌素构建小鼠糖尿病模型,通过检测连续21d灌胃不同剂量的鼠曲草黄酮对糖尿病小鼠体质量、糖耐量、糖化血清蛋白含量、肝糖原含量和血脂代谢的影响,研究鼠曲草总黄酮调节糖尿病小鼠糖脂代谢紊乱的作用。实验结果显示,连续21d灌胃鼠曲草黄酮(50mg/kg·d)可显著改善糖尿病小鼠糖耐量、降低体内的糖化血清蛋白、总胆固醇、甘油三酯、低密度脂蛋白含量,升高糖尿病小鼠的肝糖原和高密度脂蛋白水平的作用。鼠曲草总黄酮具有有效调节糖尿病小鼠糖脂代谢紊乱的作用。Activities of total flavonoids from Gnaphfium affine D.C. on blood glucose and lipid levels in diabetic mice were studied. Diabetes was induced by intraperitoneal injection of streptozotocin in mice. Changes of body weight, glucose tolerance, gfycosylated serum protein （GSP）, liver glycogen, and lipid matabolism in serum of mice were detected. Experimental results showed that the blood glucose and lipid levels disorder of diabetic mice were significantly improved by total flavonoids from Gnaphfium affine D.C. Levels of glucose tolerance ,GSP,TG,TC,and LDL-C of total flavonoids from Gnaphfium affine D.C. group were significantly decreased,and levels of liver glycogen and HDL-C significantly increased. In conclusion,total fiavonoids from Gnaphliurn affine D.C. could effectively ameliorate the blood lipid metabolism of diabetic mice.

关 键 词：鼠曲草总黄酮 糖尿病 降血糖 降血脂 

分 类 号：TS201.4[轻工技术与工程—食品科学]