气相色谱-串联质谱法测定白酒中18种邻苯二甲酸酯  

The determination of 18 phthalates in white spirits by gas chromatography-tandem mass spectrometry

作　　者：苗宏健[1] 梁栋[1] 鲁杰[1] 陈达炜[1] 梁丽娜 赵云峰[1] 

机构地区：[1]国家食品安全风险评估中心卫生部食品安全风险评估重点实验室,北京100021 [2]赛默飞世尔科技有限公司,北京100044

出　　处：《中国食品卫生杂志》2014年第3期249-254,共6页Chinese Journal of Food Hygiene

基　　金：食品接触材料中有害物质迁移量关键检测技术研究(2011BAK10B05-02)

摘　　要：目的 建立白酒中18种邻苯二甲酸酯（PAEs）的气相色谱-串联质谱（GC-MS／MS）测定方法。方法 样品中加入PAEs同位素内标，调整样品的酒精度，以甲苯萃取，采用GC—MS／MS以多反应监测模式（MRM）测定。结果 苯二甲酸二异壬酯（DINP）、邻苯二甲酸二异癸酯（DIDP）在0．1～10μg／ml，其他16种PAEs在0．01～1．0μg／ml范围内呈良好线性关系，r^2≥0．991；方法检出限为3．1～150．0μg／L，定量限为9．9～500．0μg／L；在3个加标水平下，样品平均回收率为98．5％～119．8％，RSD为0．6％～15．6％。结论本方法提高了白酒中PAEs检测的特异性，适合于白酒中多组分PAEs的同时检测。Objective A gas chromatography-tandem mass spectrometry （GC-MS/MS） method for the detection of 18 phthalates （PAEs） in white spirits was developed. Methods The samples were spiked with isotope internal standards, adjusted by alcohol concentration, and finally extracted with toluene. The supernatant were determined by GC-MS/MS. Results The calibration curves of 18 phthalates obtained were linear with correlation coefficients above 0. 991. It was effective in the determination of phthalates in white spirits. The limits of detection were 3.1-150.0 μg/L and the limits of quantification were 9.9-500. 0μg/L. The recoveries were 98.5% -119. 8% with the RSD of 0. 6%-15.6% at different spiking levels. Conclusion The method improved the specificity for PAEs detection in white spirits and was applicable for multi-component PAEs detection.

关 键 词：白酒 邻苯二甲酸酯 同位素内标稀释技术 气相色谱-串联质谱法 食品污染物 塑化剂 食品安全 

分 类 号：R155.5[医药卫生—营养与食品卫生学] O657.63[医药卫生—公共卫生与预防医学]