大肠杆菌基因中密码子前后碱基的使用与蛋白质结构  

RELATIONSHIP BETWEEN THE CONTEXT BASE USAGE OF CONDONSAND PROTEIN STRUCTURE IN ESCHERICHIA COLI GENES

作　　者：张静[1] 顾宝洪[2] 石秀凡[3] 刘次全[4] 

机构地区：[1]云南大学应用统计中心 [2]云南大学物理系 [3]中国科学院昆明动物研究所细胞与分子进化开放实验室,云南昆明650223 [4]云南大学现代生物中心,云南昆明650091

出　　处：《生物物理学报》2001年第1期174-180,共7页Acta Biophysica Sinica

摘　　要：对一组E.coli基因中编码蛋白质各类二级结构 (α -螺旋、β-折叠片、无规卷曲和回折 )的密码子前后碱基的使用情况进行统计分析和比较 ,发现一些密码子前后碱基的使用有偏向 ,而且这些偏向与蛋白质的二级结构有关联。这同时亦表明 ,E.coli基因中同义密码子的选用与蛋白质的二级结构有一些关联。模型对于蛋白质结构预测算法的改进以及基因工程的研究有辅助作用。The context base usages of codons encoding for different secondary structures (α-helix, β-sheet, coil and turn) of protein in a set of Escherichia coli genes were statistically analysed and compared. It is concluded that the context base usages of several codons are biased and the biases seem to be related to the secondary structures of protein. This result also shows that there are some correlations between the choice of synonymous codons and the secondary structures of protein in E. coli genes. The model in this paper may be useful for predicting algorithms of secondary structure of protein and gene engineering researching.

关 键 词：蛋白质二级结构 MRNA 密码子 前后碱基 使用偏向 同义密码子 大肠杆菌 基因 

分 类 号：Q939.1[生物学—微生物学] Q75