亨氏马尾藻醇提取物体内降血脂及抗氧化作用  

Hypolipidemic and Antioxidant Activity of Ethanol Extracts of Sargassum henslowianum

作　　者：吴慧 卢虹玉[2,3,4] 李梅婷[2,3,4] 章超桦 戴聪杰[5] WU Hui;LU Hong-yu;LI Mei-ting;ZHANG Chao-hua;DAI Cong-jie(Logistics Department,Guangzhou College of Technology and Business,Guangzhou 510000,China;College of Food Science and Technology,Guangdong Ocean University,Zhanjiang 524088,China;Guangdong Province Key Laboratory of Aquatic Products Processing and Safety,Zhanjiang 524088,China;Key Laboratory of Advanced Processing of Aquatic Products of Guangdong Higher Education Institution,Zhanjiang 524088,China;Fujian Province Key Laboratory for the Development of Bioactive Material from Marine Algae,Quanzhou Normal University,Quanzhou 362000,China)

机构地区：[1]广州工商学院物流系,广东广州510000 [2]广东海洋大学食品科技学院,广东湛江524088 [3]广东省水产品加工与安全重点实验室,广东湛江524088 [4]广东普通高等学校水产品深加工重点实验室,广东湛江524088 [5]泉州师范学院福建省海洋藻类活性物质制备与功能开发重点实验室,福建泉州362000

出　　处：《食品工业科技》2018年第24期313-317,共5页Science and Technology of Food Industry

基　　金：国家863计划子项目(2013AA092902):远海大型生物全新天然产物的发现与药物先导化合物优化;广东普通高等学校水产品高值化加工与利用创新团队项目(GDOU2016030503);广东省教育厅"创新强校工程"(GDOU2015050213):基于纳米微胶囊化的马尾藻多酚减肥作用研究

摘　　要：为了探究亨氏马尾藻醇提取物的降血脂和抗氧化作用,本文以溶剂法得到亨氏马尾藻醇提取物高、低两个剂量,灌胃急性小鼠高脂模型,观察马尾藻醇提取物对小鼠血脂指标的影响,并检测其在体内抗氧化活性。结果表明:亨氏马尾藻醇提取物低剂量组显著降低高脂血症小鼠血清中总胆固醇(TC)和低密度脂蛋白(LDL)含量以及其肝脏中甘油三酯(TG)和低密度脂蛋白(LDL)含量(p <0.05),脂蛋白脂肪酶(LPL)活力显著增强(p <0.05);高剂量组使血清中高密度脂蛋白(HDL)含量显著上升和低密度脂蛋白(LDL)含量显著下降以及其肝脏中甘油三酯(TG)显著降低(p <0.05);且两种剂量均可显著改善小鼠动脉粥样硬化指数AI1和AI2(p <0.05);同时,灌胃亨氏马尾藻醇提取物后,低剂量组使小鼠肝脏总抗氧化能力(T-AOC)、过氧化氢酶(CAT)活力显著上升(p <0.05),而丙二醛(MDA)水平显著降低(p <0.05),说明亨氏马尾藻醇提取物在降血脂和抗氧化作用方面具有潜在的应用。In this research,to study the hypolipidemic and antioxidant activity of ethanol extracts from Sargassum henslowianum C.Agardh,high and low doses of ethanol extracts from S. henslowianum was obtained by solven extraction. Hypolipidemic and antioxidant activities of extracts of S. Henslowianum in vivo were detected by establishment of acute hyperlipidemia mouse models.The results showed that low doses of extracts from S. henslowianum significantly reduced (p < 0.05) the levels of total cholestero (TC),low density lipoprotein-cholestero (LDL) in serum and triglyceride (TG),low density lipoprotein-cholestero (LDL) in liver,but lipoprotein lipase (LPL) activities in serum were increaed (p < 0.05); while the high doses increaed significantly contents of high density lipoprotein-cholesterol (HDL) and reduced the levels of low density lipoprotein-cholestero (LDL) in serum,and the levels of triglyceride (TG) in liver (p < 0.05).The atherosclerosis index AI1 and AI2 of hyperlipidemia mice were improved significantly by gavage low and high doses of extracts from S.henslowianum (p < 0.05).Also,low doses of ethanol extracts of S.henslowianum improved effectively the mice antioxidant levels in vivo,which increased significantly totalantioxidant capacity and catalase (CAT),and decreased significantly the content of malondialdehyde (MDA) in liver.So ethanol extracts of S.Henslowianum have potential applications in hypolipidemic and antioxidant.

关 键 词：亨氏马尾藻 醇提取物 降血脂 抗氧化 

分 类 号：TS254.4[轻工技术与工程—水产品加工及贮藏工程]