赭曲霉毒素A的微生物脱毒研究进展  

Bio-detoxification of Ochratoxin A by Microorganism

作　　者：贾欣[1] 徐诗涵 梁志宏[1] 黄昆仑[1] 

机构地区：[1]中国农业大学食品科学与营养工程学院,北京100083

出　　处：《生物技术通报》2014年第12期18-23,共6页Biotechnology Bulletin

基　　金：国家高技术研究发展计划("863"计划)(2012AA101609-7);教育部(2011JS119)

摘　　要：赭曲霉毒素A(Ochratoxin A,OTA)是一类聚酮化合物,是由曲霉属(Aspergillus spp.)和青霉属(Penicilliumspp.)等霉菌产生的次级代谢产物,具有强烈毒性。近年来,国内外已有大量关于OTA生物脱毒的研究,主要是OTA脱毒功能菌株的筛选,包括细菌、霉菌和酵母菌等。此外,对不同微生物脱毒机理的探索也是研究热点。对上述两方面的研究进展进行归纳和讨论。Ochratoxin A （ OTA ） is a class of polyketides, which are secondary metabolites produced by Aspergillus spp. and Penicillium spp., having a strong toxicity. In recent years, there are a large number of domestic and international researches on OTA biological detoxification, mainly on screening strains of OTA detoxifieation, iiacluding bacteria, molds and yeasts and so on. In addition, exploring different microbial detoxification mechanism is also a research hotspot. In this paper, these two aspects Of progress were summarized and discussed.

关 键 词：生物脱毒 赭曲霉毒素A 细菌 真菌 肠道微生物 

分 类 号：Q939.9[生物学—微生物学]