肌醇磷脂对高脂血症大鼠血脂的影响  

Effect of phosphatidylinositol on blood lipid in rats

作　　者：张泽生[1] 王芮[1] 张丽[1] 王霄然 

机构地区：[1]天津科技大学食品工程与生物技术学院,天津300457

出　　处：《中国食品添加剂》2014年第9期74-79,共6页China Food Additives

摘　　要：目的:探究肌醇磷脂是否具有降血脂功效。方法:建立高脂动物模型,给实验大鼠灌胃灌胃不同浓度的肌醇磷脂样品(105mg/kg·BW、210 mg/kg·BW、420 mg/kg·BW),同时设立阳性对照组,灌胃与中剂量等量的卵磷脂。饲养8周后,股动脉取血后检测各项相关指标。结果:与模型组相比,高剂量组血清中的总胆固醇(TC)、甘油三酯(TG)和非高密度脂蛋白(non-HDL-C)指标均有极显著地降低(P<0.01)。与空白组相比,模型组血清和肝脏中的超氧化物歧化酶(SOD)水平显著降低(P<0.05),血清和肝脏中丙二醛(MDA)含量极显著增加(P<0.01);与模型组相比,剂量组血清和肝脏中的超氧化物歧化酶(SOD)水平显著降低(P<0.05),血清和肝脏中丙二醛(MDA)含量极显著增加(P<0.05)。与阳性对照组相比,剂量组各指标均无显著性。结论:肌醇磷脂对高脂血大鼠血脂水平有降低作用,同时具有抑制脂质过氧化的作用。同时肌醇磷脂的降血脂效果与卵磷脂相当。Objective ： To explore the effect of Phosphatidylinositol on lowering blood lipid. Methods ： It established the animal model of the high- blood lipid. The experimental rats were given by gavage once a day with different PI （ 105mg/kg . BW ,210 mg/kg . BW ,420 mg/kg . BW）. To set up the positive control group was given by garage with 210mg/kg . BW lecithin simuhaneously. Hyperlipidemic indicators were tested after collecting serum samples. Re- suits： Compared with the model group, the concentration of total cholesterol（ TC）, non- high density lipoprotein cho- lesterol（ non- HDL- C）and triglyceride（TG） in serum exhibited a significant decrease in serum from the high -dose group（P 〈0. O1 ）. Compared with the normal group, the MDA contents in serum and liver were increased（ P 〈 0. 01 ） and the SOD activity in serum and liver were deceased（ P 〈 0.05 ）in the model group. Furthermore, compared with the model, the MDA contents in serum and liver were deceased（ P 〈 0. 05 ）and the SOD activity in serum and liver were in- creased（ P 〈 0. 05 ） in the high - dose group. And then, the high - dose group hadnt significant difference with the pos- itive control group. Conclusion： Phosphatidylinositol has an obvious effect on lowering blood lipid and inhibiting lipid peroxidation in rats.

关 键 词：大豆磷脂 肌醇磷脂 大鼠 降血脂 

分 类 号：TS202.1[轻工技术与工程—食品科学]