Fat cell-secreted adiponectin mediates physical exercise-induced hippocampal neurogenesis: an alternative anti-depressive treatment?  

作　　者：Suk Yu Yau Ang Li Aimin Xu Kwok-fai So 

机构地区：[1]State Key Laboratory of Brain and Cognitive Sciences,Li Ka Shing Faculty of Medicine,The University of Hong Kong [2]Division of Medical Sciences,University of Victoria BC,Canada [3]Department of Anatomy,The University of Hong Kong [4]Department of Medicine,The University of Hong Kong [5]Department of Pharmacology and Pharmacy,The University of Hong Kong [6]Research Centre of Heart, Brain,Hormone and Healthy Ageing,The University of Hong Kong [7]State Key Laboratory of Pharmaceutical Biotechnology,Li Ka Shing Faculty of Medicine,The University of Hong Kong [8]Department of Ophthalmology,The University of Hong Kong [9]Guangdong-Hong Kong-Macao Institute of CNS Regeneration,Jinan University [10]Guangdong Key Laboratory of Brain Function and Diseases,Jinan University

出　　处：《Neural Regeneration Research》2015年第1期7-9,共3页中国神经再生研究（英文版）

基　　金：supported by Hong Kong Health and Medical Research Fund;Leading Talents of Guangdong(2013);Programme of Introducing Talents of Discipline to Universities(B14036);Project of International,as well as Hong Kong,Macao&Taiwan Science and Technology Cooperation Innovation Platform in Universities in Guangdong Province,China(2013gjhz0002);grants to Jinan University Guangdong-Hong Kong-Macao Cooperation and Innovation Center for Tissue Regeneration and Repair;State Key Laboratory of Pharmaceutical Biotechnology,Hong Kong SAR,China

摘　　要：Psychological depression is drawing accumulating attention nowadays, due to the skyrocketing incidence worldwide and the enormous burdens it incurs. Physical exercise has been long recog- nized for its therapeutic effects on depressive disorders, although knowledge of the underlying mechanisms remains limited. Suppressed hippocampal neurogenesis in adult brains has been regarded, at least partly, contributive to depression, whereas physical exercise that restores neuro- genesis accordingly exerts the anti-depressive action. Several recent publications have suggested the potential role of adiponectin, a protein hormone secreted by peripheral mature adipocytes, in mediating physical exercise-triggered enhancement of hippocampal neurogenesis and alleviation of depression. Here, we briefly review these novel findings and discuss the possibility of counter- acting depression by modulating adiponectin signaling in the hippocampus with interventions including physical exercise and administration of pharmacological agents.Psychological depression is drawing accumulating attention nowadays, due to the skyrocketing incidence worldwide and the enormous burdens it incurs. Physical exercise has been long recog- nized for its therapeutic effects on depressive disorders, although knowledge of the underlying mechanisms remains limited. Suppressed hippocampal neurogenesis in adult brains has been regarded, at least partly, contributive to depression, whereas physical exercise that restores neuro- genesis accordingly exerts the anti-depressive action. Several recent publications have suggested the potential role of adiponectin, a protein hormone secreted by peripheral mature adipocytes, in mediating physical exercise-triggered enhancement of hippocampal neurogenesis and alleviation of depression. Here, we briefly review these novel findings and discuss the possibility of counter- acting depression by modulating adiponectin signaling in the hippocampus with interventions including physical exercise and administration of pharmacological agents.

关 键 词：HIPPOCAMPUS adult neurogenesis physical exercise voluntary wheel running depression neural progenitor cell ADIPOCYTE ADIPONECTIN adiponectin receptor AMP-activated protein kinase 

分 类 号：R749.4[医药卫生—神经病学与精神病学]