食用菌超细粉免疫调节和抗氧化功能研究  

Enhancing immunomodulatory and antioxidant functions of superfine edible mushroom flour

作　　者：杨文建[1] 孙勇[2,3] 袁彪[2] 赵立艳[2] 安辛欣[2] 陈慧婵[2] 刘凌冉 胡秋辉[2] 

机构地区：[1]南京财经大学食品科学与工程学院,江苏南京210023 [2]南京农业大学食品科技学院,江苏南京210095 [3]北京市食品研究所,北京100162

出　　处：《菌物学报》2015年第2期301-310,共10页Mycosystema

基　　金：农业部现代农业产业技术体系建设专项(CARS-24)

摘　　要：以糙皮侧耳、双孢蘑菇、金针菇、3个黑木耳品种、3个香菇品种为材料,通过测定小鼠体重、免疫器官重量、细胞免疫功能、体液免疫功能、单核-巨噬细胞的吞噬功能、血清及肝脏中谷胱甘肽过氧化物酶、超氧化物歧化酶、肝脏中白介素-6、丙二醛等指标进行小鼠免疫功能的评价研究。结果表明:"四川青川"香菇、"北神奇1号"黑木耳和"黑龙江黑29"黑木耳能显著增强小鼠的细胞免疫功能;糙皮侧耳、"辽宁恒仁"香菇、金针菇、"北神奇1号"黑木耳、"黑龙江黑29"黑木耳均能显著促进小鼠单核吞噬细胞的吞噬能力,增强小鼠机体的免疫力;糙皮侧耳、"四川青川"香菇、"辽宁恒仁"香菇、金针菇和"黑龙江黑29"黑木耳具有提高小鼠肝脏中白介素-6含量的作用;双孢蘑菇、"福建古田"香菇、"辽宁恒仁"香菇、金针菇增加小鼠血清溶血素水平,具有显著的特异性体液免疫增强作用。此外,双孢蘑菇、金针菇、"北神奇1号"黑木耳、"吉林黑29"黑木耳均可显著提高血清和肝脏中的GSH-PX活性;糙皮侧耳能提高小鼠血清中和肝脏中SOD活性;从而达到清除自由基和抗氧化损伤的作用。综合上述结果,9种食用菌超细粉均具有显著增强小鼠免疫调节能力和抗氧化作用,为食用菌功能食品产品开发利用提供支撑。Effect of Pleurotus ostreatus, Agaricus bisporus, Flammulina velutipes, three strains of Auricularia auricula and three strains of Lentinula edodes mushrooms on mouse body weight, immune organ weights, cellular immune functions, humoralmmune functions, the phagocytosis of mononuclear macrophages, GSH-Px and SOD activities in serum and liver, and nterleukin-6 and MDA levels in the liver have been invest ＂Bei 1＂ and ＂Hei 29＂ effectively enhanced cellular immun ga ty. ted. The results showed that L. edobes ＂O, ingchuan＂ and A. auricula P. ostreatus, L. edobes ＂Hengren＂, F. velutipes, and A. auricula ＂Be 1＂ and ＂Hei 29＂ improved mice monocye phagocytic capacity. P. ostreatus, L. edobes ＂Qingchuan＂ and ＂Hengren＂, F. velutipes increased the levels of IL-6 in liver. A. bisporus, L. edobes ＂Gutian＂, L. edobes levels of serum hemolysin in mice. A. bisporus, F. velutipes, and A. auricula activities in serum and liver. P. ostreatus improved SOD activity in serum and and antioxidant functions on mice of these nine mushrooms＇ superfine flours ＂Hengren＇; F. velutipes, and P. eryngii increased the ＂Bei 1＂ and ＂Jilin 29＂ effectively promoted GSH-Px vet. The results indicated the immunomodulatory

关 键 词：食用菌 小鼠实验 免疫调节 抗氧化 

分 类 号：R285.5[医药卫生—中药学]