Repressors of reprogramming  

作　　者：Melissa Popowski Haley Tucker 

机构地区：[1]the Rockefeller University, New York [2]Institute for Cellular and Molecular Biology,University of Texas at Austin

出　　处：《World Journal of Stem Cells》2015年第3期541-546,共6页世界干细胞杂志（英文版）（电子版）

摘　　要：Induced pluripotent stem cells(i PSCs) have been the focal point of ever increasing interest and scrutiny as they hold the promise of personalized regenerative medicine. However, creation of i PSCs is an inefficient process that requires forced expression of potentially oncogenic proteins. In order to unlock the full potential of i PSCs, both for basic and clinical research, we must broaden our search for more reliable ways of inducing pluripotency in somatic cells. This review surveys an area of reprogramming that does not receive as much focus, barriers to reprogramming, in the hope of stimulating new ideas and approaches towardsdeveloping safer and more efficient methods of reprogramming. Better methods of i PSC creation will allow for more reliable disease modeling, better basic research into the pluripotent state and safer i PSCs that can be used in a clinical setting.Induced pluripotent stem cells （iPSCs） have been thefocal point of ever increasing interest and scrutiny asthey hold the promise of personalized regenerativemedicine. However, creation of iPSCs is an inefficientprocess that requires forced expression of potentiallyoncogenic proteins. In order to unlock the full potentialof iPSCs, both for basic and clinical research, we mustbroaden our search for more reliable ways of inducingpluripotency in somatic cells. This review surveysan area of reprogramming that does not receive asmuch focus, barriers to reprogramming, in the hopeof stimulating new ideas and approaches towardsdeveloping safer and more efficient methods ofreprogramming. Better methods of iPSC creation willallow for more reliable disease modeling, better basicresearch into the pluripotent state and safer iPSCs thatcan be used in a clinical setting.

关 键 词：REPROGRAMMING INDUCED PLURIPOTENCY STEM CELLS 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]